None listed
Conditions
Brief summary
Diabetes and cardiovascular diseases remain the major cause of preventable ill health and premature death in developed nations. This burden is shared across both genders, although there is far less known in women than men. Following menopause, women experience a rapid increase in metabolic health risk, yet predictive detection is lacking. Diabetes and cardiovascular (heart) diseases have a metabolic basis, in that metabolic processes are altered. Current research suggests that these metabolic alterations are not present under fasting conditions, but may become evident in response to a stimuli (or challenge). In this study we aim to recruit women and following a meal either rich in rapidly digested (high glycaemic) or slowly digested (low glycaemic) carbohydrates take blood samples. These blood samples will be analysed for metabolites (or chemical signatures) that identify metabolic pathway differences. This research can provide new insights into detecting early risks or metabolic abnormalities that place some women at increased risk of ill-health.
Interventions
Iso-energetic meals of high protein with high glycaemic index carbohydrates or high protein with low glycaemic index carbohydrates. The meal will be consumed for breakfast after an overnight fast (7pm-7am) and followed by a one week wash out period between study meals. The meals will consist of 30% protein, 20% fats and 50% carbohydrates. The glycaemic index of the low glycemic meal will be approximately 30 and the High glycaemic meal will be approximately 75. The two meals have an energy content of 590 kcal or 2470kJ.
Sponsors
Study design
Eligibility
Inclusion criteria
Female, postmenopausal, BMI 18-34
Exclusion criteria
BMI outside of the range 18-34. History of cancer or heart disease or exisiting diagnosis of diabetes