None listed
Conditions
Brief summary
This study aims to investigate if, following anaesthesia related healthcare inteventions, individuals with higher levels of inflammation at baseline, have a higher rate of postoperative cognitive dysfunction at 3 months after surgery. Participants will be having surgery with an expected stay of 3 or more days and consent to neuropsychological testing and having bloods taken during their hospital stay. Cognitive and memory testing will take place prior to surgery and at 3 months after surgery. Tests for delirium will also be conducted during the participants time in hospital.
Interventions
Observation study of elderly patients (60 years and older) undergoing healthcare interventions requiring surgery and anaesthesia. Patients will undergo baseline and 3 month neuropsychological testing prior to and following surgery. The two neuropsychological tests take roughly one hour and are completed at the patient's home. During the hospital stay patients will have blood samples taken prior to anaesthetic induction, at 30 minutes post surgical incision and also at 6, 24 and 48 hours followin
Observation study of elderly patients (60 years and older) undergoing healthcare interventions requiring surgery and anaesthesia. Patients will undergo baseline and 3 month neuropsychological testing prior to and following surgery. The two neuropsychological tests take roughly one hour and are completed at the patient's home. During the hospital stay patients will have blood samples taken prior to anaesthetic induction, at 30 minutes post surgical incision and also at 6, 24 and 48 hours following surgery. Blood samples will be analysed for inflammatory markers.
Sponsors
St Vincent's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Aged 60 years or older 2. Scheduled for elective health care procedure 3. No contraindication to neuropsychological testing (eg. language, significant depression, deaf or blind) 4. Live within a reasonable proximity of St Vincent's Hospital (for home neuropsychological assessments) 5. Expected length of hospital stay of 3 days or more
Exclusion criteria
1. Pre-existing neurological or clinically evident nerovascular disease (eg stroke) 2. Mini Mental State Examination of 26 and below 3. Anticipated difficulty with neuropsychological assessment 4. Inaccessibility (patients living over 1 hour drive from Melbourne) 5. Age (patients less than 60 years of age) 6. Anticipated length of stay in hospital less than 3 days
Outcome results
None listed