None listed
Conditions
Brief summary
Obstructive sleep apnoea (OSA) is a condition involving repeated episodes of partial or complete blockage of the airway during sleep. Learning difficulties, behavioural problems as well as bed-wetting, sleep-walking, retarded growth, other hormonal and metabolic problems and even failure to thrive can be related to sleep apnoea. Children diagnosed with OSA usually undergo surgical removal of the tonsils and adenoids. However, there is a high rate of complications with approximately 50% of the children suffering from minor or major breathing problems during and/or after surgery requiring specialised care. Additionally, the younger the children are, the higher the risk of breathing problems, which have a potential for serious harm to their health. The impact on the healthcare system is significant; the number of unplanned admissions necessitating specialised treatment with prolonged hospital stays increases causing delays on theatre lists. This leads to potential cancellations of other children due to the lack of theatre time and consequently increases the waitlist time. Currently the pre-operative assessment by the ENT surgeon determines whether the child will be managed as a day case or a ward patient. In case of the latter, it is further distinguished if the child gets normal ward care, specialised ward care or whether an admission to the intensive care unit is required. If the child has not been sent to the preoperative anaesthetic clinic (which is the case for the majority of children), the anaesthetist on the day of surgery might need to organise more specialised care if he/she does not agree with the care pre-organised, which may lead again to cancellations. Currently, preoperative assessment relies heavily on the surgeons and the anaesthetists’ pre-operative diagnosis. It usually involves using a clinical questionnaire that relies mostly on parental observation and interpretation of symptoms to accurately identify the presence of OSA and grade its severity accordingly. Once the grade of OSA has been established, the risk of perioperative respiratory complications can be better established and preventative strategies can be implemented where deemed necessary. However the rate of complication and unplanned admissions remain high. This is due to the grading of OSA being impacted by the high variability in the answers to the clinical questionnaire; different parents interpret the same symptoms differently and thus introduce a high bias in the OSA grading. A more appropriate approach to diagnosis and grading OSA with a much higher degree of accuracy would be the use of a scientific marker that can easily, quickly and safely be measured at the point of care. It is well known and has been shown in the literature that children with OSA have upper airways that are more prone to collapse during sleep and thus anaesthesia. Thus measuring the propensity of upper airway collapse may provide the treating team with more accurate physiological data to grade OSA and consequently narrow down the variability in the estimated probability of perioperative respiratory adverse events. Our team of respiratory and sleep physiology experts have developed and trialled a quick, safe and easy technique to measurement the propensity of upper airway collapsibility in adults and with this study we are aiming to identify whether this technique can be used in everyday clinical practice during peri-operative management to screen children with OSA who are at a higher risk of perioperative respiratory adverse events (PRAE).
Interventions
Measuring the propensity of upper airway collapse may provide more accurate physiological data to grade Obstructive Sleep Apnoea (OSA) and consequently narrow down the variability in the estimated probability of perioperative respiratory adverse events. The study will start by the screening for the presence of obstructive sleep apnoea. Measurements of airway collapsibility pressure will be carried out at two different perioperative phases; (1) Just after induction of anaesthesia and prior to insertion of the airway device (2) At emergence just after the removal of the airway device Upper airway collapsibility pressure will be measured at the above two timepoints. Each measurement will be between 15 and 30 seconds and repeated twice to give an accurate result. This involves the use of a nasal mask and requires the patient to be breathing spontaneously while anaesthesia is maintained. A pressure transducer will continuously measures pressure changes within the nasal mask. Airflow and phase of respiratory cycle will be monitored either by a pneumotachograph attached to the nasal mask, or by visually monitoring the patient’s chest wall movement. After ensuring that the nasal mask is leak free by optimising the seal, at end-expiration it will be occluded and the pressure-time profile monitored for evidence of ‘flattening’ - indicating upper airway collapse. (Breathing will be blocked for between 15 to 30 seconds.) The pressure at which this occurs (termed Pclose) will be recorded. Once the flattening of the curve is observed, the nasal mask is removed and breathing returns to normal. Air flow will be monitored for all patients to ensure adherence to the protocol. All results of airway collapsibility will be recorded in a study data collection log.
Sponsors
Study design
Eligibility
Inclusion criteria
Male or female Aged 1 to 8 years of age Undergoing elective surgery under general anaesthetic for tonsillectomy (+/- adenoids, myringotomy, and/or cautery of inferior turbinates)
Exclusion criteria
Need for premedication with midazolam. Contraindication for the use of sevoflurane Inability to give informed consent Children with known cardiopulmonary disease Significant medical disease or condition that is likely to interfere with the protocol or might be confounded by the protocol.