None listed
Conditions
Brief summary
The ingestion of excess energy, particularly fat, is largely responsible for the current epidemic of lifestyle-related diseases such as obesity, diabetes and sarcopenia (the progressive loss of muscle mass with increasing age). The development of sarcopenia is exacerbated by low levels of physical activity and also in overweight or obese individuals through an increase in body fat and concomitant decrease in muscle mass. However, performing resistance and aerobic exercise in combination with the ingestion of high-quality protein sources (e.g., dairy-based protein) has been shown to enhance and/or maintain muscle mass. This has important health implications for reducing the risk of developing sarcopenia, obesity or other debilitating health conditions such as diabetes. Accordingly, the aim of this research is to investigate whether high fat levels decreases the muscle growth response following resistance and endurance exercise and protein ingestion.
Interventions
36 participants will be recruited for this study. There will be 3 experimental groups to which participants will be randomly and equally assigned:
Group 1: Control Trial
The control group will be administered a constant infusion of saline (400 mL 0.9% saline) for 4 hours prior to consuming a 500 mL (total) of a protein beverage (~30 g of whey protein).
Group 2: Lipid (Fat) Emulsion Trial
The lipid emulsion group will be administered a constant infusion of lipid (fat) emulsion (400 mL 20% intr
36 participants will be recruited for this study. There will be 3 experimental groups to which participants will be randomly and equally assigned: Group 1: Control Trial The control group will be administered a constant infusion of saline (400 mL 0.9% saline) for 4 hours prior to consuming a 500 mL (total) of a protein beverage (~30 g of whey protein). Group 2: Lipid (Fat) Emulsion Trial The lipid emulsion group will be administered a constant infusion of lipid (fat) emulsion (400 mL 20% intralipid) for 4 hours prior to consuming a 500 mL (total) of a protein beverage (~30 g of whey protein). Group 3: Exercise Trial Participants in the exercise trial will be administered a constant infusion of lipid (fat) emulsion (400 mL 20% intralipid) for 4 hours. During the first hour of this infusion, participants will undertake a non-strenuous exercise session consisting of 30 minutes cycling at 50% of aerobic capacity. Participants will then complete a resistance exercise session consisting of an appropriate warm-up and then 6 sets of 10 repetitions at 75% of pre-determined maximum strength level of leg extension. At the end of the 4 hour infusion, participants will consume a 500 mL (total) protein beverage (~30 g whey protein) exactly the same as in the control trial. Participants in each of the three groups will then rest throughout a 4 h recovery period during which additional skeletal muscle biopsies will be obtained at 2 hours and 4 hours following the ingestion of the protein drink.
Sponsors
Prof John Hawley
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
Male
Age
35 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
Male, physically inactive subjects who are overweight, i.e., a BMI of 27-32 kg/m2 but otherwise apparently healthy. Physically inactive is defined by less than 150 min of moderate-to-vigorous physical activity per week.
Exclusion criteria
Physically active, type II diabetics, insulin resistant, alcoholics or smokers.
Outcome results
None listed