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12 weeks of single-leg cycling in individuals with coronary artery disease

In individuals with stable coronary artery disease, does single-leg cycling improve functional capacity greater than double-leg cycling?

Status
Withdrawn
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12615000935538
Enrollment
60
Registered
2015-09-08
Start date
2018-04-02
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

60 participants will be recruited to complete 12 weeks of either single-leg high intensity interval cycling or double-leg high intensity interval cycling. This study aims to determine the functional, psychosocial and physiological effects of cycle exercise training using either one or two legs. This will be a parallel randomised group design recruiting individuals 18-80 years of age with established coronary artery disease.

Interventions

Participants with stable heart disease will be randomised to one of two exercise groups involving 12 weeks of different forms of cycling. One group will undertake single-leg high intensity interval cycle training and the second group will undertake double-leg high intensity interval cycle training. All exercise intensities will be prescribed according to a predetermined level of perceived exertion, using the Borg 6-20 rating of perceived exertion (RPE) scale, which is associated with a desired

Participants with stable heart disease will be randomised to one of two exercise groups involving 12 weeks of different forms of cycling. One group will undertake single-leg high intensity interval cycle training and the second group will undertake double-leg high intensity interval cycle training. All exercise intensities will be prescribed according to a predetermined level of perceived exertion, using the Borg 6-20 rating of perceived exertion (RPE) scale, which is associated with a desired percent of aerobic capacity (VO2peak). Each session will begin and end with a 5 minute double-leg cycling based warm-up (intensity; RPE 11-13, 40-60% VO2peak) and cool down (intensity; RPE 8-10, 20-40% VO2peak), followed by a 20 minute resistance circuit, as is standard practice in cardiac rehabilitation programs. During the double-leg high intensity interval sessions, the participant will complete ten 30 second double-leg efforts at an RPE 15-17 (60-85% VO2peak) with each effort separated by 60 seconds of passive rest (RPE 6; <20% VO2peak). During the single-leg high intensity interval sessions, participants will complete ten 30 second single-leg efforts at an RPE of 15-17 with each effort separated by 60 seconds of passive rest (RPE 6). At the completion of the first ten efforts, a short break will be provided (~5 minutes) prior to the participant completing another ten efforts with the opposite leg. 3 sessions per week will be prescribed and monitored by Miss Nicole Gordon, an ESSA Accredited Exercise Physiologist. Program adherence will be monitored through exercise logs.

Sponsors

Murdoch University
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

Individuals with established coronary artery disease assessed by angiography, a history of an acute coronary syndrome, or elective percutaneous coronary intervention or coronary artery bypass grafting surgery.

Exclusion criteria

Individuals less than 6 months after an acute cardiac event or surgery, signs or symptoms of myocardial ischaemia at rest, or in response to maximal exercise testing, left ventricular ejection fraction < /= 45%, moderate to severe aortic stenosis, a history of complex ventricular arrhythmias, uncontrolled diabetes mellitus or hypertension, recent medication change (<2 weeks), or orthopaedic or neurological disorders.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026