None listed
Conditions
Brief summary
The primary purpose of this study is to investigate if people with Parkinson's disease have the usual reduction in pain threshold following exercise (i.e. exercise induced analgesia). We hypothesize that people with Parkinson's disease will have the usual exercise-induced analgesia response to exercise. The secondary purpose is to investigate the relationships between measures of exercise-induced analgesia with pain, physical activity levels, sleep quality and mood in people with Parkinson’s disease and the relationships between physical activity levels, sleep quality, mood and pain in people with Parkinson’s disease. We hypothesize that increased physical activity, better sleep and better mood will be associated with a better exercise-induced analgesia response and with less pain in people with Parkinson's disease.
Interventions
All participants will be asked to perform one short bout of isometric upper limb exercise, in order to assess exercise induced analgesia/hyperalgesia. First, the participant’s maximal voluntary force will be determined by asking them to maximally contract their muscles against a force transducer. This procedure will be repeated two more times with the participant’s maximal voluntary contraction (i.e. 1RM) being the greatest force produced during the 3 trials. Following a short rest, participants
All participants will be asked to perform one short bout of isometric upper limb exercise, in order to assess exercise induced analgesia/hyperalgesia. First, the participant’s maximal voluntary force will be determined by asking them to maximally contract their muscles against a force transducer. This procedure will be repeated two more times with the participant’s maximal voluntary contraction (i.e. 1RM) being the greatest force produced during the 3 trials. Following a short rest, participants will be asked to sustain an isometric contraction at a moderate intensity (i.e. 40% 1RM) for as long as possible with a maximum time of 3 minutes. Following the assessment session, participants with PD will be asked to wear an activity and sleep monitoring device on their wrist and their waist for 7 consecutive days.
Sponsors
The University of Sydney
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Aged 40 years or over, living in the community. Participants with Parkinson's disease will be required to have had no changes to their usual Parkinson's disease medications in the prior 2 weeks.
Exclusion criteria
People with neurological impairments other than those due to Parkinson's disease. People with substantial cognitive impairment (i.e. mini-mental state examination below 24) People with pain due to a known radiculopathy (i.e. a compressed nerve of the spine) or another diagnosed chronic pain condition (e.g. fibromyalgia) that is likely to interfere with the evaluation of the person’s safety and of the study outcome. People with an upper limb problem which would preclude the upper limb isometric exercise. People without Parkinson's disease who experience significant pain (i.e. pain of >3/10 intensity for at least 2 days per week in the prior 3 months)
Outcome results
None listed