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Does infiltration of local anaesthesia improve recovery after anterior hip replacement?

A prospective randomised double-blind placebo-controlled parallel-group two-arm superiority trial to determine the efficacy of local infiltration analgesia for anterior total hip replacement.

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12615000844549
Acronym
LIA
Enrollment
160
Registered
2015-08-14
Start date
2016-04-20
Completion date
2018-08-28
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Major joint replacement surgery has an important role in improving the quality of life for many people. As Australia’s population grows and ages, joint replacement surgery will be performed more often. In 2014, over 11,000 hip joint replacements were performed in Victoria alone. Improved postoperative and longer-term mobility and comfort provides benefits not just for an individual, but also for the whole community. The anaesthetist’s role as a perioperative physician means that one clinical responsibility is to provide patients with rapid recovery to an appropriate level of function. This can be achieved by providing effective analgesia, which can be administered well, with few side effects. In practice, there is sometimes a trade-off in the balance between these goals. The widely used technique of infiltrating local anaesthetic into the hip joint during surgery is simple, with seemingly few side-effects. It is usually used together with analgesics such as paracetamol, anti-inflammatories and morphine tablets. However, recent studies have questioned its effectiveness at reducing pain in the traditional surgical approach to hip replacement. To date, no study has examined its effectiveness in the setting of less invasive surgery (anterior hip replacement). We aim to determine whether adding intraoperative local anaesthetic infiltration to standard multimodal oral analgesia will improve recovery after anterior hip replacement. 160 participants will be randomly allocated to receive infiltration of local anaesthetic or saline placebo during surgery. Any improvement in general wellbeing and mobility, or reduction in postoperative pain, will have a positive impact on a large surgical population. A negative result will provide evidence that the local anaesthetic infiltration technique should no longer be used for pain relief after anterior hip replacement surgery.

Interventions

This study will be a prospective, randomised, double-blind, placebo-controlled, parallel-group, two-arm superiority trial. Eligible participants will be aged 50-80 years undergoing primary unilateral anterior THR for osteoarthritis. Participants will be assigned to intraoperative periarticular infiltration of 2.5ml/kg of 0.2% ropivacaine or 0.9% saline. All other care, including anaesthetic technique, postoperative analgesia and mobilisation programs, will be the same for both groups.

Sponsors

Dr Nicole Tan
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

Patients aged 50 - 80 years undergoing primary unilateral anterior THR for osteoarthritis, who are able to provide informed consent.

Exclusion criteria

Patients will not be eligible if they take regular opioids other than codeine, have an allergy or contraindication to the proposed analgesic or anaesthetic technique, ASA > 3, BMI > 40, are pregnant, have undergone lower limb joint replacement in the preceding 6 months or are scheduled for any further surgery within 30 days.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026