None listed
Conditions
Brief summary
Prophylactic antibiotic choice and dosing during paediatric cardiac surgery using cardiopulmonary bypass remains poorly defined. Cardiac surgery should be associated with an incidence of infection (superficial and deep) < 5%. This target is not reached in many centres. One contributing factor is a lack of understanding of antibiotic pharmacokinetics during support with extracorporeal circuits. Dosing may not achieve desired concentrations in the body. Children undergoing cardiac surgery will receive routine antibiotic prophylaxis. Blood concentrations will be monitored. Population pharmacokinetic modelling will be used to determine a dosing regimen to achieve desired target concentration.
Interventions
Pharmacokinetic analysis of antibiotic disposition in children undergoing cardiac surgery with cardiopulmonary bypass. Antibiotics (cephazolin, vancomycin) are given intravenously during the procedure only. The first dose is at induction of anaesthesia. A second dose is commonly given at the conclusion of cardiopulmonary bypass. They are not continued into the postoperative period. A dosing log will be kept.
Sponsors
Brian Anderson
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Healthy volunteers
No
Inclusion criteria
children with heart disease presenting for surgery that requires extracorporeal circuits
Exclusion criteria
refusal by parent/caregiver or child for consent known allergy to antibiotic
Outcome results
None listed