None listed
Conditions
Brief summary
Only a few patients (less than 10%) survive cardiac arrest that lasts for more than 30 minutes, even if the cause is potentially reversible. ECMO is a blood pump that can be placed in large blood vessels in the groin and takes over the functions of the heart and lungs. This study will look at how many people survive persisting cardiac arrest when ECMO is used to support the heart until the cause of the cardiac arrest has been treated and the heart has had time to recover.
Interventions
Mechanical chest compressions with a Lucas Device, commenced either in-hospital (cardiac arrest team) or out-of-hospital (by paramedics)
Induced hypothermia with 2L of intravenouse ice-cold saline, commenced by paramedics, Emergency Department or ICU staff.
Peripheral veno-arterial ECMO support (by anaesthetists and surgeons) to facilitate early revascularisation (if indicated) by cardiologists.
Neurological prognostication will be performed at 96 hours to determine limits of therapy.
The ove
Mechanical chest compressions with a Lucas Device, commenced either in-hospital (cardiac arrest team) or out-of-hospital (by paramedics) Induced hypothermia with 2L of intravenouse ice-cold saline, commenced by paramedics, Emergency Department or ICU staff. Peripheral veno-arterial ECMO support (by anaesthetists and surgeons) to facilitate early revascularisation (if indicated) by cardiologists. Neurological prognostication will be performed at 96 hours to determine limits of therapy. The overall duration of ECMO support is anticipated to be approximately 2-5 days
Sponsors
A/Prof Paul Forrest
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
12 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
In-and out-of-hospital cardiac arrest, refractory to conventional ACLS Witnessed cardiac arrest Potentially reversible aetiology No major known co-morbidities
Exclusion criteria
Known major co-morbidities
Outcome results
None listed