The COLDICE Trial: Cryobiopsy versus Open Lung biopsy in the Diagnosis of Interstitial lung disease allianCE

Conditions

None listed

Brief summary

The transbronchial lung cryobiopsy is a new, minimally invasive technique for obtaining lung tissue to diagnose ILD. In order to determine the place of cryobiopsy in ILD diagnostic algorithms and international guidelines, it is crucial that this procedure is validated against the current gold-standard practice, the VATS biopsy. This study brings together a team of leading proceduralists, ILD specialists and histopathologists from across Australia, with consultative input from international leaders in the field. The main objective of this project is to determine the role of cryobiopsy in the diagnosis of ILD.

Wendy A. Cooper, Annabelle Mahar, Jeffrey L. Myers, Christopher Grainge, Tamera J. Corte et al. (14 authors)

American Journal of Respiratory and Critical Care Medicine2020-12-0755 citations

10.1164/rccm.202009-3688oc

Diagnostic accuracy of transbronchial lung cryobiopsy for interstitial lung disease diagnosis (COLDICE): a prospective, comparative study.

Troy LK, Grainge C, Corte TJ, Williamson JP, Vallely MP, Cooper WA, Mahar A, Myers JL, Lai S, Mulyadi E, Torzillo PJ, Phillips MJ, Jo HE, Webster SE, Lin QT, Rhodes JE, Salamonsen M, Wrobel JP, Harris B, Don G, Wu PJC, Ng BJ, Oldmeadow C, Raghu G, Lau EMT, Cryobiopsy versus Open Lung biopsy in the Diagnosis of Interstitial lung disease alliance (COLDICE) Investigators.

2019-09-29245 citations

10.1016/s2213-2600(19)30342-x

Cryobiopsy versus open lung biopsy in the diagnosis of interstitial lung disease (COLDICE): protocol of a multicentre study

Lauren Troy, Christopher Grainge, Tamera J. Corte, Jonathan Williamson, Michael P. Vallely et al. (15 authors)

BMJ Open Respiratory Research2019-06-0120 citations

10.1136/bmjresp-2019-000443

Interventions

Transbronchial lung cryobiopsy - a recently developed technique involving the bronchoscopic insertion of a frozen-tipped probe into peripheral airways for extraction of lung tissue specimens for diagnostic purposes. This will take between 30-45 minutes in most cases.

Study design

Allocation

Non-randomised trial

Intervention model

Single group

Primary purpose

Diagnosis

Masking

Blinded (masking used) (Investigator)

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Healthy volunteers

No

Inclusion criteria

Patients assessed as requiring histopathology for the diagnosis of their ILD (at specialist multidisciplinary team meetings), and considered suitable for VATS lung biopsy.

Exclusion criteria

* Age > 80 * Resting oxyhaemoglobin saturation under 90% * Platelets less than 100 * INR > 1.5 * Advanced comorbidities (including poorly controlled systemic hypertension, congestive cardiac failure, unstable angina, significant stroke). * History of of adverse reaction to general anaesthesia * Inability to provide informed consent * Systolic pulmonary artery pressure over 40mmHg on echocardiogram or evidence of right ventricular dysfunction * Inability to withhold anti-platelet therapy (eg aspirin or clopidogrel)

Outcome results