None listed
Conditions
Brief summary
Men who have sex with men tested positive for pharyngeal gonorrhoea at Melbourne Sexual Health Centre (MSHC) who volunteer will be randomised to receive an alcohol-containing mouthwash or a saline on the day when they receive treatment for pharyngeal gonorrhoea. The primary outcome is the proportion of cases who test positive for pharyngeal gonorrhoea by culture after gargling an alcohol-containing mouthwash.
Interventions
Participants in the intervention arm will be asked to rinse and gargle a 20 mL alcohol-based mouthwash (i.e. Listerine) for 60 seconds under direct observation with a stopwatch before they receive standard treatment for pharyngeal gonorrhoea on the day. The standard treatment for pharyngeal gonorrhoea is Ceftriaxone 500mg in 2mL of 1% lignocaine as a single intramuscular injection plus a single dose of oral capsule Azithromycin 1 gram. All participants will be asked to rinse and gargle once only
Participants in the intervention arm will be asked to rinse and gargle a 20 mL alcohol-based mouthwash (i.e. Listerine) for 60 seconds under direct observation with a stopwatch before they receive standard treatment for pharyngeal gonorrhoea on the day. The standard treatment for pharyngeal gonorrhoea is Ceftriaxone 500mg in 2mL of 1% lignocaine as a single intramuscular injection plus a single dose of oral capsule Azithromycin 1 gram. All participants will be asked to rinse and gargle once only, and no follow-ups and adherence to the intervention is required in this study.
Sponsors
Alfred Health
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Men who have sex with another men in the past 12 months. Men who have a positive throat N. gonorrhea (GC) on nucleic acid amplification tests (NAATs)
Exclusion criteria
Men who had been treated prior to result for gonorrhoea with the standard treatment of Ceftriaxone 500 mg as a single dose. Men treated with Azithromycin 7 days prior
Outcome results
None listed