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The effects of 4 week of arachidonic acid supplementation muscle protein synthesis following resistance exercise in resistance trained young men

The effects of 4 week of arachidonic acid supplementation on Muscle protein synthesis following resistance exercise in resistance trained young men

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12615000710527
Enrollment
19
Registered
2015-07-09
Start date
2015-05-18
Completion date
2016-06-08
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Resistance trained men will undergo 4 week of supplementation with 1.5 g per day of arachidonic acid or a placebo. They will then complete an acute bout of resistance exercise. Muscle biopsies will be collated at 1.5, 4 and 48 hours after the exercise. It is hypothesized that arachidonic acid supplementation will increase the rate of muscle protein synthesis and the muscle satellite cell to a greater extent than placebo following the acute exercise bout.

Interventions

4 weeks of daily supplementation with 1.5 g of arachidonic acid via oral capsule. Supplement is consumed twice daily: 0.75 g (two capsules) in the morning and 0.75 g (two capsules) prior to exercise or in the evening if no exercise is preformed. Subjects will continue their normal exercise routine during the supplementation period. Supervised acute exercise will take place in the morning following the 28th day (4th week) of supplementation. The supplement will not be consumed the morning of th

4 weeks of daily supplementation with 1.5 g of arachidonic acid via oral capsule. Supplement is consumed twice daily: 0.75 g (two capsules) in the morning and 0.75 g (two capsules) prior to exercise or in the evening if no exercise is preformed. Subjects will continue their normal exercise routine during the supplementation period. Supervised acute exercise will take place in the morning following the 28th day (4th week) of supplementation. The supplement will not be consumed the morning of the acute exercise session. The acute exercise intervention will consist of 8 sets of both leg press and leg extension at 80% 1RM. With 2 min rest between sets.

Sponsors

University of Auckland
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
Male
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

A history of resistance training for greater than one year. Including training the lower body at least once per week.

Exclusion criteria

Medical conditions or medication use anabolic steroid use omega 3 or 6 supplement in the previous month

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026