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Extra pulmonary Water quantification by PiCCO system in edema reperfusion after pulmonary endarterectomy

Extra pulmonary Water quantification by PiCCO system in edema reperfusion after pulmonary endarterectomy

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12615000685516
Acronym
PiCCO
Enrollment
32
Registered
2015-07-01
Start date
2015-01-21
Completion date
2015-05-11
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

One of the most common and most serious after pulmonary endarterectomy thromboembolic (PET) complications is edema reperfusion. Monitoring by transpulmonary thermodilution is commonly used in intensive care. It could allow a quantitative measurement of reperfusion edema by objective measurement and study its possible associations with the hemodynamic and ventilatory parameters.

Interventions

Main objective is to study the amount variations of pulmonary water measured by simple thermodilution during the first 48 hours in the intensive care after Pulmonary endarterectomy. The PiCCO-Technology allows monitoring by a minimally invasive method, hemodynamic and volumetric parameters. PiCCO technology is based on transpulmonary thermodilution and contour analysis of the pulse wave. Data thermodilution and analysis of pulse wave are collected using a pulmonary artery catheter and a central

Main objective is to study the amount variations of pulmonary water measured by simple thermodilution during the first 48 hours in the intensive care after Pulmonary endarterectomy. The PiCCO-Technology allows monitoring by a minimally invasive method, hemodynamic and volumetric parameters. PiCCO technology is based on transpulmonary thermodilution and contour analysis of the pulse wave. Data thermodilution and analysis of pulse wave are collected using a pulmonary artery catheter and a central venous catheter inserted into the jugular position operating room. A first series of thermodilutions transpulmonary is formed by injection on a center line of the right jugular, three boluses of 15 ml of cold physiological saline solution at 4 degrees Celsius temperature. If there was a difference in cardiac output value of more than 20% between thermodilutions two other thermodilutions are performed. The measured values are the average of three thermodilutions and the extreme values are removed. They also show the values of volumes and analysis of the pulse wave intra-thoracic. Data is collected once a day, an hour after the patient arrival in intensive care unit, and 24 and 48 hours after surgery.

Sponsors

Centre Chirurgical Marie Lannelongue
Lead SponsorHospital

Study design

Allocation
Non-randomised trial
Intervention model
Other
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

It is important that patients respond to following condition: -hospitalization stay in ICU estimate superior than or equal to 3 days. - Catheter Swan Ganz functional - arterial catheter in Femoral position

Exclusion criteria

- Need circulatory and respiratory assistance as ECMO - Pulmonary endarterectomy failure - The inability to establish a femoral arterial catheter - A Swan Ganz catheter nonfunctional

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026