None listed
Conditions
Brief summary
the primary purpose of the study is to determine is there a difference in brain volume between growth restricted, average for gestational age and small for gestational age fetuses. the study hypothesis is that growth restricted feuses have smaller brain volumes that may be related to their adverse perinatal outcomes.
Interventions
intrauterine growth restriction(IUGR) has well recognized and long term consequences.because not all fetuses found to be small in utero have true growth restriction, the distinction of true growth restriction from constitutional smallness has been one of the goals of the fetal medicine over the last 20 years. doppler ultrasound has been one of the most valuable techniques to distinguish sick IUGR from the well IUGR.Recently 3D ultrasound has been gradually introduced as valuable complementary
intrauterine growth restriction(IUGR) has well recognized and long term consequences.because not all fetuses found to be small in utero have true growth restriction, the distinction of true growth restriction from constitutional smallness has been one of the goals of the fetal medicine over the last 20 years. doppler ultrasound has been one of the most valuable techniques to distinguish sick IUGR from the well IUGR.Recently 3D ultrasound has been gradually introduced as valuable complementary tool for fetal evaluation offering the possibility of calculating fetal organ volumes and providing extra information on growth and maturation. the objective of our study is to analyze the possible existance of differences in the fetal brain volume between growth restricted fetuses with brain sparing , small for gestational age fetuses (SGA) with normal Doppler, and average for gestational age fetuses(AGA) and if it is possible to predict postnatal outcome depending on brain volume. in our study all patients will be subjected to conventional abdominal ultrasonography for measurments of BPD,HC, FL, AC ,of their fetuses between 32-36 weeks gestation with estimation of expected fetal weight (Hadlock 1990), Doppler ultrasonography of middle cerebral artery and umbilical artery to measure pulsatility index and resistance index and detailed 3D ULtrasound to detect brain volume . fetal biometry and 3d measurments of brain volume is done every 2 weeks for all patients. Doppler velocimetry is done every 2 weeks in AGA group, every week in SGA group, twice weekly or even daily in IUGR group. all measurments are done from enrolment till delivery
Sponsors
department of obstetrics and gynecology ,cairo univeristy, Egypt
Eligibility
Sex/Gender
All
Age
22 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
IUGR group includes pregnant women between 32 and 36 weeks of gestation with estimated fetal weights less than the 10th centiles for gestational age with brain sparing defined as MCA-PI less than 5th centile for gestational age. small for gestational age group between 32-36 weeks of gestation with estimated fetal weights less than the 10th centile for getational age and normal Doppler indices , group of average for gestational age between 32-36 weeks of gestation with estiated fetal weights between 10th and 90th centliles. all are singleton prgnancies with no structural anomalies by ultrasound
Exclusion criteria
fetuses with congenital anomalies, and those didn,t deliver in our institution
Outcome results
None listed