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The effect of early breastfeeding on maternal oxidative stress.

Does early breastfeeding in the operating room during cesarean section effect maternal oxidative stress and antioxidant capacity, a randomised controlled study

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12615000682549
Acronym
-
Enrollment
90
Registered
2015-07-01
Start date
2015-06-01
Completion date
2015-07-01
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

After birth with cesarean section, mothers and neonates are exposed to oxidative stress. Human milk contains components that protect the infant from infections and the oxidative stress caused during transition from intrauterine to extrauterine life. Human milk is very well known to have antioxidative properties. Brest-fed children were shown to have higher antioxidative capacity in blood and lower oxidative stress compared to formula-fed infants (Szalagatys 2004, Korchazhkina 2006). In many hospitals in Turkey, our usual practice during cesarean section is handling the baby to a neonatal team, consisting of pediatricians or a mid-wife, who remove the baby to a radiant warmer right after birth and giving the baby back to mother in the ward, after one or two hours period of observation in the recovery room. Immediate skin to skin care and early breastfeeding, was shown to promote maternal-neonatal bonding and thermoregulation of the infants (Burke- Aaronson, 2015) as well as reducing the delay of lactation and the likelihood of formula supplementation (Stevens 2014). Implementing immediate skin to skin care is recommended in many latest international reports for the well being of the neonate (Crenshaw 2014, Burke-Aaronson 2015). Besides the well known positive effects on the infants, the effect of skin to skin contact and early breastfeeding on maternal oxidative stress and antioxidant capacity is not studied before. In this study, we aim to find whether or not early breastfeeding during cesarean section, prevents the maternal oxidative stress. In addition, we also aim to analyse whether there is any correlation between the maternal oxytocin levels and total antioxidant capacity or total oxidant status. Our secondary aim in this study is to evaluate the relation between postoperative pain and postoperative oxytocin levels.

Interventions

Immediate skin to skin contact during ceserean section, right after the delivery of the baby, will be maintained for ten minutes between the mother and the child. The breastfeeding will be provided in the operating room during this contact. In the postoperative period, maternal oxidative stress and antioxidant capacity will be measured. The correlation between maternal oxidative stress and antioxidant capacity will be analysed.

Sponsors

Beril Yuksel
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

Healthy pregnant patients, between age 18 and 35, who will have an elective ceserean section with regional (spinal) anesthesia.

Exclusion criteria

The pregnant patients who have any systemic disease, cuagulation abnormalities, preeclampsia, eclampsia, acute or chronic fetal distress, multiple pregnancies or preterm labour.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026