Postprandial effect of krill oil supplementation in healthy female subjects

Investigation of the postprandial effect of krill oil supplementation on fatty acid metabolism and cardio-metabolic risk factors in healthy females

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12615000620527

Enrollment

Registered

2015-06-15

Start date

2014-07-15

Completion date

2014-11-04

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The health benefits of long-chain n-3 polyunsaturated fatty acids from krill oil and fish oil are associated with the incorporation of EPA and DHA into the cell membrane which then alters the membrane structure and cell functions. Consequently they reduce plasma triglyceride level and inhibit inflammatory response. The bio-availability of these fatty acids from the two oils maybe different due to the binding of fatty acids in the oils. This study will evaluate the incorporation of EPA and DHA into the plasma and chylomicron after a single dose supplementation. In addition the effects on cardio-metabolic risk factors will also be investigated.

Interventions

Ingestion of 5 x 1g krill oil capsules (containing 833 mg EPA + 471 mg DHA) with breakfast once (in the teaching clinic) followed by 1 week washout period, and Ingestion of 5 x 1g of fish oil capsules (containing 1037mg EPA + 745 mg DHA) with breakfast once (in the teaching clinic) followed by 1 week washout period. Standardised breakfast (150g mashed potatoes with 600mL water) is provided. The breakfast is mixed with the intervention oil by the researcher before serving to the participants. The

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Prevention

Masking

Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy females aged 18-45 years and have not experienced menopause, body mass index (BMI) between 20 and 30 (kg/m2).

Exclusion criteria

Cigarette smoker; all types of heart, liver or kidney disease, diabetes; pregnancy; lactating; medications of cholesterol lowering, antihypertension, anti-inflammation, anti-coagulation or anti-depression; omega-3 or antioxidant supplements in the past four weeks prior to the study.

Outcome results