None listed
Conditions
Brief summary
The purpose of this study is to determine if steroids used at the time of surgery reduce pain, nausea and vomiting, and reduce length of stay in patients undergoing total hip or knee arthroplasty procedures.
Interventions
Two doses of 8mg of dexamethasone are given intravenously. The first dose is given immediately pre-operatively and the second dose given 24 hours post surgery. The syringe with the Dexamethasone will be provided to the operating room and ward by the pharmacy.
Sponsors
Jonathan Mulford
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
- People who are presenting to preadmission clinic for single joint hip or knee arthroplasty. - Able to provide informed consent - Age 18 years and older
Exclusion criteria
- Type 1 or type 2 diabetes mellitus; renal failure; hepatic failure - Use of oral corticosteroids over past 6 months - Allergic or adverse reaction to corticosteroids in the past - Allergy to the food preservative Sulfite (this does not include Sulpha containing medications) - Active peptic ulcer disease with symptoms present in the previous 6 months - Previous GIT haemorrhage - Pregnancy and lactation - Past history of psychotic illness (including psychotic depression) - Current systemic fungal infection - Administration of live vaccine in the previous 3 months - Myasthenia gravis
Outcome results
None listed