None listed
Conditions
Brief summary
Stroke is a leading cause of chronic disability in many developed countries, causing both physical and cognitive impairments. Research strongly suggests that exercise rehabilitation can help with these impairments. However, on closer inspection, it is evident that there is little clear consensus on what type of exercise (aerobic or resistance) results in attenuating vascular risk factors to the greatest degree. As such, there is limited evidence available to help guide best practice. In the acute and subacute phase of stroke care, getting the balance right between diagnosis, the start of therapies, medical interventions and exercise rehabilitation can be challenging. Improving our understanding of the impact of exercise and nutrition interventions on vascular and functional restoration should be a priority. The purpose of this research study is therefore to investigate the effect of aerobic exercise, resistance exercise, the combination and nutrition (following stroke diagnosis) on vascular risk factors and arterial stiffness in newly diagnosed non- disabling stroke and transient ischemic attack (TIA) patients. It is hypothesized that participation in a 12 week aerobic exercise program will Lead to significantly greater changes then: Resistance exercise alone Combination of resistance and aerobic exercise Usual care control group Nutrition group
Interventions
Baseline assessment - finger prick samples to measure blood profile markers. 12-lead ECG exercise stress test, to sub-maximal exhaustion (8mins) and images of the carotid artery via a pulsecor.
Exercise Intervention - 12 weeks, 40mins x 2 p/wk
ARM 1
Aerobic - 40mins of aerobic exercise -Starting at 75% HRR with an increment of 10% every 4th week i.e. 75%, 85%. 95% HRR. Protocol = interval training – 1min exercise; 15secs rest. Completed on treadmill or stationery ergometer.
ARM 2
Resistance
Baseline assessment - finger prick samples to measure blood profile markers. 12-lead ECG exercise stress test, to sub-maximal exhaustion (8mins) and images of the carotid artery via a pulsecor. Exercise Intervention - 12 weeks, 40mins x 2 p/wk ARM 1 Aerobic - 40mins of aerobic exercise -Starting at 75% HRR with an increment of 10% every 4th week i.e. 75%, 85%. 95% HRR. Protocol = interval training – 1min exercise; 15secs rest. Completed on treadmill or stationery ergometer. ARM 2 Resistance - 40mins of circuit-resistance exercise – Starting at 75% HRR with an increment of 10% every 4th week i.e. 75%, 85%. 95% HRR. Protocol = interval training – 1min exercise; 15secs rest of 8 exercises (upper and lower body) x 4 sets ARM 3 12-weeks of Nutritional education and group sessions, 2 x 45-60mins p/wk, will be undertaken at Wellington Hospital or other identified location for cooking demonstrations by dieticians. The nutritional guidance will be based on a whole foods plant based diet. Patients will be educated on the benefits of such a diet in regards to vascular risk factor control and reversal of atherosclerosis. Continued sessions will also concentrate on how to achieve this type of diet through group sessions and cooking demonstrations Strategies to improve adherence: Exercising in a group setting Clinical Exercise Physiologists present at each exercise session to help monitor and ensure safety of participants
Sponsors
Massey University
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
Inclusion criteria – located within CCDHB; diagnosed with non-disabling stroke/TIA by stroke physician. ABCD2 > 4 for those diagnosed with TIA for an indication of severity.
Exclusion criteria
Exclusion criteria includes: oxygen dependence, uncontrolled angina, unstable cardiac conditions, uncontrolled diabetes mellitus, febrile illness, claudication, significant cognitive impairment and immobility.
Outcome results
None listed