Effects of oligofructose and inulin in management of chronic nonspecific diarrhoea of childhood – intervention study

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We included patients aged 1 to 5 years old, with at least 5 episodes of diarrhea in the last 6 months fulfilling the criteria of chronic nonspecific diarrhea. The first 31 patients represented the interventional group, named Group A, and the next 23 patients were in the control group (marked as Group B). Group A received a combination of oligofructose and inulin, 4 g/day, divided in 2 daily oral doses for a period of 3 months, and Group B received only dietary recommendations, according to the current guideline. The follow up evaluation included 6 medical visits, the first visit was at the time of inclusion, the second was after 2 weeks, the 3rd visit was after another 2 weeks, the 4th and 5th visits were performed every 30 days and the 6th visit took place after 3 months. The first end point was obtained by comparing clinical efficiency evaluated using gastrointestinal symptoms (vomiting, abdominal pain, constipation) marked with Yes/No answers and counted as episodes per period between visits, number of acute episodes (defined as increased stool frequency with changes of stool consistency) appreciated according to the Bristol Stool Form Scale, where 1 represents hard stools, 7 indicates watery stools, scores lower than 5 indicate normal stool, and the duration of acute episodes is defined as the time from the first loose stool, until at least 12 hours without stool. The second end point consisted of hospitalization (Yes/No answers and the duration of hospitalization according to medical files), use of antibiotics (Yes/No answers were registered), safety and efficiency appreciated by a questionnaire completed by parents in terms of treatment efficiency and acceptance (very good/ good/ moderate were the answers options).

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