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Does transcutaneous electrical acupoint stimulation alleviate remifentanil-induced hyperalgesia in patients undergoing thyroidectomy: a randomized controlled trial

Does transcutaneous electrical acupoint stimulation alleviate remifentanil-induced hyperalgesia in patients undergoing thyroidectomy: a randomized controlled trial

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12615000496516
Enrollment
60
Registered
2015-05-19
Start date
2015-03-05
Completion date
2015-05-27
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Transcutaneous electric acupoint stimulation (TEAS), a non-invasive technique, can be applied by personnel with minimal training. Several clinical trials have demonstrated that TEAS has the potential to reduce postoperative pain and perioperative analgesic consumption. However, the effects of TEAS on remifentanil induced hyperalgesia remains unknown. Therefore, we designed this prospective, randomized, double-blind study to verify the hypothesis TEAS can alleviate remifentanil induced hyperalgesia in patients undergoing thyroidectomy.

Interventions

Patients in the TEAS group were performed TEAS for 30 min before the induction of anesthesia in the holding area. TEAS was applied to two pairs of acupoints: bilateral Hegu (LI4) and Neiguan (PC6).The acupoints were stimulated with a dense-disperse frequency of 2/10 Hz and an intensity of 6–9 mA for 30 min, using the Hans electronic acupuncture apparatus (HANS-100A, Nanjing Jisheng Medical Technology Company, Nanjing, China).

Sponsors

Yusheng Yao, Department of Anesthesiology,Fujian Provincial Hospital
Lead SponsorIndividual

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
No

Inclusion criteria

We enrolled 60 ASA I-II consecutive female subjects, aged 18 to 60 years, who scheduled for elective thyroidectomy under general anesthesia.

Exclusion criteria

Potentially difficult airway, a history of chronic pain, drug or alcohol abuse, intake of any analgesic drug within 48 h before surgery, mental disorder, bradycadia, diabetes, pregnancy, and previous experience with acupuncture treatment.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026