None listed
Conditions
Brief summary
Randomised control trial of IV and oral paracetamol to assess the efficacy of pain relief. This project could act as a pilot study to form a basis for more extensive research to support the introduction of IV paracetamol for certain ED populations We hypothesize that patients receiving the IV paracetamol will have a more rapid reduction in pain score, larger reduction in pain scores and require less rescue analgesia than patients in the oral paracetamol group.
Interventions
Arm 1: paracetamol 1 gram, intravenous as a single dose
Arm 2: paracetamol 1 gram, oral as a single dose
Sponsors
The Townsville Hospital and Health Service
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Age greater than or equal to 18years Already has intravenous access or has a clinical condition indicating that intravenous access is required Have received at least one initial dose of morphine (either with Queensland Ambulance Service or in ED) with ongoing pain score >40mm on the Visual Analogue Scale (VAS) at > 5 minutes post administration of morphine or equivalent.
Exclusion criteria
Any state (e.g. intoxicated) or medical history (e.g. mental health disorder) impairing accurate pain assessment Known/suspected to have drug dependence Allergic to paracetamol Received or taken paracetamol in the last 6 hours Known or suspected Renal or hepatic insufficiency Pregnant Currently enrolled in other clinical trials for the treatment of pain Unable to safely swallow oral medication
Outcome results
None listed