Collection and banking of fresh tumours for frozen storage for patients undergoing planned excision of tumours

Patients with solid tumours that are accessible can bank their tumours in a dedicated tumour bank for long term fresh frozen storage conditions for the possible future production of an autologous cancer vaccine, the latter being a separate study.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12615000476538

Enrollment

Registered

2015-05-14

Start date

2015-08-05

Completion date

2017-12-12

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The objective of this project is to collect tumour tissue from patients undergoing elective surgery for the removal of primary tumour or metastases. Who is it for? You may be eligible to participate in this project if you are aged 18 years or above and are planning to undergo surgery as routine treatment for cancer from which tumour can be sourced. Study details: Participants in this project will undergo routine tumour removal surgery as planned. A tumour sample is obtained from this surgery and put into long term frozen storage for up to 3 years. The tissue may be used for potential manufacture into an autologous therapeutic cancer vaccine for use within the same patient, at a time in the future should that patient’s medical oncologist recommend this treatment. This future treatment is a separate project.

Interventions

There is no intervention. A sample of tumour will be taken from routine, planned tumour removal surgery. The sample will go into long term frozen storage. The tumour sample may be used in the future to manufacture an autologous cancer treatment vaccine. The tumour will be stored for an initial period of up to 3 years.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

- Adults 18 years of age and over - Planned surgery as routine treatment for cancer from which tumour can be sourced - In the investigator's opinion, has a tumour of a size that is likely to yield at least 1 cm3

Exclusion criteria

- Treatment for cancer in the 4 weeks prior to tumour excision surgery - Current or past history of active autoimmune disease - Known HIV infection - Chronic hepatitis - History of organ transplant or other condition requiring immunosuppressant medications - Chronic systemic corticosteroid therapy

Outcome results