None listed
Conditions
Brief summary
Analgesic effects of intravenous parecoxib have been investigated in orthopedic surgery. Postoperative pain is still a common problem after total knee arthroplasty. Recent studies have shown that intraarticular bupivacaine injection has analgesic effect after total hip replacement and good opioid-sparing effect at the first 12 hours after hip surgery. Local anesthetic is injected into intraarticular cavity after surgical wound closure, spreading into muscle and soft tissue, which can effectively decrease postoperative pain. In view of this, we hypothesized that intraarticular bupivacaine in combination with intravenous parecoxib might improve postoperative pain relief in patients receiving total knee arthroplasty.
Interventions
Analgesic effects of intravenous parecoxib have been investigated in orthopedic surgery. Postoperative pain is still a common problem after total knee arthroplasty. The purpose of this double-blind, randomized study was to investigate whether the addition of intraarticular bupivacaine to intravenous parecoxib could improve pain relief in patients receiving total knee arthroplasty. One hour before operation, a single dose of parecoxib 40 mg was injected intravenously within 30 seconds. After the
Analgesic effects of intravenous parecoxib have been investigated in orthopedic surgery. Postoperative pain is still a common problem after total knee arthroplasty. The purpose of this double-blind, randomized study was to investigate whether the addition of intraarticular bupivacaine to intravenous parecoxib could improve pain relief in patients receiving total knee arthroplasty. One hour before operation, a single dose of parecoxib 40 mg was injected intravenously within 30 seconds. After the closure of the surgical wound, a single dose of intraarticular injection of 0.5% bupivacaine 60 ml (300 mg) was given into the joint space within 2 minutes.
Sponsors
Huang-Ping Yu
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
patient with knee osteoarthritis who was indicated for total knee arthroplasty
Exclusion criteria
neuropathic pain or sensory disorder in the knee required surgery, coagulation abnormalities, severe renal or hepatic impairment, and chronic opioid use
Outcome results
None listed