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Insulin-induced weight gain in type 2 diabetes

Weight gain one year after insulin initiation for type 2 diabetes

Status
Completed
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12615000462583
Enrollment
340
Registered
2015-05-12
Start date
2014-11-01
Completion date
2015-02-02
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This project aims to determine: 1. the prevalence of weight gain in patients with T2DM who are treated with insulin at RMH; 2. the impact of weight gain on clinical variables such as blood pressure and lipid levels; and 3. to find factors that predict the occurrence of weight gain in people with type-2 diabetes treated with insulin. Hypothesis:Weight gain prevalence will be greater than 60% in the studied population of type 2 diabetics treated with insulin. This weight gain will be variable depending on baseline characteristics such as starting weight, insulin characteristics and use of oral hypoglycaemics. Patients who gain weight will show a worsening of their cardiovascular risk profile when compared to those who do not.

Interventions

Patients with type 2 diabetes who are commenced on insulin while attending the Royal Melbourne Hospital Diabetes Clinic. Observation from 6 months before insulin initiation up to 18 months after. Patients included if there was weight data available within this time period, from 1998 to 2014.

Sponsors

Melbourne Health
Lead SponsorHospital

Eligibility

Sex/Gender
All
Age
29 Years to 90 Years
Healthy volunteers
No

Inclusion criteria

Patients with type 2 diabetes who started insulin while attending Royal Melbourne Hospital (RMH) Diabetes clinic, with a baseline weight at insulin initiation defined as up 6 months before to 2 months after and a 1 year weight (at 11 to 18 months)

Exclusion criteria

type 1 diabetes, gestational diabetes, secondary diabetes, no weight data in specified times, insulin commenced before attending clinic at RMH

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026