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The effect of temperature change during operation of obesity.

Study to examine if anesthesia during laparoscopic abdominal surgery induces thermoregulatory response changes in the obese.

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ANZCTR
Registry ID
ACTRN12615000375550
Enrollment
60
Registered
2015-04-23
Start date
2015-05-11
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Background: Hypothermia is the most common thermoregulatory disorder encountered during anesthetic methods and it can cause complications. Subcutaneous fat tissues increse in the obese. Therefore, aim of this study has observed whether anesthesia induced thermoregulatory respones changes in the obese. Methods: Our study will include 60 patients aged 18-60 years within the American Society of Anesthesiologists (ASA) I-III risk group who will scheduled for laparoscopic abdomen surgery. Patients will divide into two groups according to body mass index (in Group II, BMI< 24.9 and Group I > or equal 30). Probes for measuring the nasopharengeal membrane and peripheral temperature will place in patients, and their mean skin temperature and mean body temperature will assess immediately before the induction of anesthesia and 5, 10, 15, 20, 30, 45, 60, 90 and 120 minutes after the induction of anesthesia. Shivering score will record at postanesthesia care unit.

Interventions

60 patients will be enrolled in the study with laparoscopic abdominal surgery under general anesthesia. Patients will be divided into two groups according to body mass index (Group I: if BMI is equal ot greater than 30 and Group II: if BMI is below than 24.9). In all cases, to avoid errors in body temperature measurements arising from the diurnal rhythm, body temperature measurements were taken in the morning between 08:30 and 13:00 hours. After preoxygenation with 100% O2, intravenous induction

60 patients will be enrolled in the study with laparoscopic abdominal surgery under general anesthesia. Patients will be divided into two groups according to body mass index (Group I: if BMI is equal ot greater than 30 and Group II: if BMI is below than 24.9). In all cases, to avoid errors in body temperature measurements arising from the diurnal rhythm, body temperature measurements were taken in the morning between 08:30 and 13:00 hours. After preoxygenation with 100% O2, intravenous induction of anesthesia was obtained with 2-2,5 mg/kg propofol 0.6mg/kg rocuronium and 0.1 mcg/kg remifentanyl. After endotracheal intubation, anesthesia was maintained with 5-6% desflurane in 50% air-50% O2. Respiration was continued mechanically and was adjusted to 30 to 40 mmHg ETCO2. In addition, to partially humidify and heat inhaled gases, a disposable humidifier was added to the breathing circuit. When necessary, patients were given additional doses of remifentanyl infusion and rocuronium. To remove the residual muscle relaxant effects during recovery from anesthesia, 0.04 mg/kg neostigmine, and when required, 0.01 mg/kg intravenous atropine was used. When laryngeal reflexes and adequate spontaneous breathing returned, the patients were extubated. The patients's temperature will follow every 5 minutes during operating room and postanesthetic care unit. Temperatures will record from central temperature, axillary, wrist, finger, thigh, cruris.

Sponsors

Ayse Belin OZER
Lead SponsorIndividual

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years
Healthy volunteers
No

Inclusion criteria

The study was included 60 patients aged between 18-60 years whose physical status was in the American Society of Anesthesiologists (ASA) I-III risk group and were scheduled for laparoscopic abdominal surgery.

Exclusion criteria

Patients with inflammatory diseases, diabetes mellitus, muscle disease, hypo/hyperthyroidism, cardiac, hepatic and renal diseases, Parkinson disease, Reynold syndrome, a history of using drugs that are known to affect body temperature (Beta-blockers, calcium channel blockers, clonidine, steroids, anti-epileptic, non-steroidal anti-inflammatory drugs, benzodiazepine), drug and alcohol addiction, obesity were excluded from the study. In addition, patients whose surgery was shorter than 60 minutes and longer than 180 minutes were also excluded from the study. Patients having a greater than 30% change in hemodynamic parameters during the surgery, those who needed to use a vasopressor or vasodilator, and those who required a blood transfusion were excluded from the study as well.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026