None listed
Conditions
Brief summary
Galectin-3 is beta-galactoside binding protein that plays active role in immune modulation, cell interaction, cancer progression and in pathogenesis of infectious diseases (Jones JL, 2010). As a member of Galectin protein family, Galectin-3 is available in both cell cytoplasm and nucleus (Fukumori T, 2007). Galectin-3 (Gal-3) plays role in apoptosis and prolifertaion. Recently, Gal-3 has been associated with embryo implantation and related with uterine receptivity (Yang H et al, 2012). Gal-3 has also been detected in spermatogenetic cells, epydidimis, Sertoli cells, vas deferens, prostat, seminal vesicle and in sperm protein extracts. To date, many in-vivo studies have evaluated Gal-3 nd finally have revealed association between this protein and implantation process. However, no study have elucidated Gal-3 levels with regard to fertilization process of sperms. Our aim is to investigate the seminal plasma Gal-3 levels of subjects undergoing in vitro fertilization treatment with different indications and to reveal outcomes.
Interventions
Seminal Plasma Galectin-3 levels in patients with male factor infertility undergoing assisted reproductive techniques (ART) and relation of Galectin-3 levels with sperm parameters and cycle outcomes. Sperm samples will be collected on a single occasion only at the time of assisted reproductive services.
Sponsors
Ufuk University School of Medicine
Eligibility
Sex/Gender
Male
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
male factor infertility without prior history of testicular surgery age between 18-40 with partner age of 18-40 normal karyotype
Exclusion criteria
-Subjects with prior testicular surgery -Subjects undergoing assisted reproductive techniques with genetic screening -Subjects under age 18 or above 40 -Subjects under medication resulting with altered sperm production -Subjects with severe metabolic disorder
Outcome results
None listed