None listed
Conditions
Brief summary
We want to study the effect of nebulized budesonide on oxygenation and respiratory mechanics when used in conjunction with recruitment maneuver in patients with ALI/ARDS
Interventions
60 patients admitted to the ICU due to ALI/ARDS assigned to two groups:budesonide group(30 patients) where 1mg-2 ml budesonide suspension is nebulized through the endotracheal tube,while in the control group(30 patients) 2 ml isotonic saline is nebulized instead of budesonide.This regimen is applied twice daily for three successive days.Nebulization is performed using specific ventilator nebulized (Aeroneb pro-Aeroneb professional nebulized system Aerogen( Ireland) with an oxygen flow of 8 lite
60 patients admitted to the ICU due to ALI/ARDS assigned to two groups:budesonide group(30 patients) where 1mg-2 ml budesonide suspension is nebulized through the endotracheal tube,while in the control group(30 patients) 2 ml isotonic saline is nebulized instead of budesonide.This regimen is applied twice daily for three successive days.Nebulization is performed using specific ventilator nebulized (Aeroneb pro-Aeroneb professional nebulized system Aerogen( Ireland) with an oxygen flow of 8 liters/ min. The duration of each Nebulization session is 15 minutes. before each session, recruitment manoeuvre is done by increasing peak airway so as to get a plateau pressure of 30 cm. H2o for 30 seconds.
Sponsors
South valley university
Study design
Allocation
Randomised controlled trial
Primary purpose
Treatment
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Patients should fulfill the criteria of ALI/ARDS according to 2012 Berlin definition of ALI/ARDS
Exclusion criteria
Refusal of consent by relatives,age <18 or>65 years,chronic obstructive pulmonary disears,restrictive respiratory insufficiency,increased intracranial pressure, bronchpleural fistula,acute myocardial infarction and neuromuscular disease.
Outcome results
None listed