Effect of adding ketamine infusion to propofol sedation on hemodynamic changes and recovery in patients undergoing elective lower limb surgery under spinal anaesthesia

Addition of ketamine infusion to propofol sedation with spinal anesthesia in patients undergoing elective lower limb surgery: Hemodynamic changes, Recovery Profile

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12615000372583

Enrollment

Registered

2015-04-23

Start date

2014-07-07

Completion date

2014-10-06

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

We tried to evaluate the difference between two sedation drugs with the route of ; propofol alone intravenous infusion and ketamine-propofol combined intravenous infusion. We studied during lower limb surgery with spinal anesthesia. And observed patients hemodynamic values, mini mental state examination scores, postoperative events, satisfaction scores.

Interventions

Intravenous infusions of propofol alone and ketamine combined with propofol during sedation. In group P: Propofol infusion dose is 25-75 mcg/kg/min and titrated according to Ramsey Sedation Score. In group KP: Propofol was managed like in Group P and ketamine dose is 1/3 of propofol in terms of mg.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Caregiver)

Eligibility

Sex/Gender

All

Age

25 Years to 80 Years

Healthy volunteers

Inclusion criteria

25-80 years old Both gender Candidate of elective lower limb surgery Do not have contraindications for spinal anesthesia

Exclusion criteria

Patients with a allergic reaction to propofol or ketamine, obesity (BMI greater than or equal to 35) , uncontrolled hypertension ( greater than 170/100mmHg), clinically significant cardiac, pulmonary, hepatic, renal dysfunction, psychiatric disorders, neurologic impairment were exluded from study.

Outcome results