Hospital-Based Early Intervention for Posttraumatic Stress Disorder

Randomised Controlled Trial of Cognitive Therapy with either Memory Reactivation or Control Condition for Adults to prevent Posttraumatic Stress Disorder Following Traumatic Injury

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12615000355572

Enrollment

240

Registered

2015-04-20

Start date

2016-01-01

Completion date

2017-11-01

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The rationale of the study is to evaluate the roles of memory reactivation and cognitive therapy as a means of preventing PTSD shortly after trauma exposure. This study compares the relative effectiveness of (a) Cognitive Therapy Combined with Memory Reactivation, (b) Cognitive Therapy Alone, and (c) Wait-list in reducing posttraumatic stress disorder symptoms. It is hypothesised that Cognitive Therapy combined with Memory Reactivation will lead to greater symptom reduction than Cognitive Therapy, which will lead to greater symptom reduction than Wait-List.

Interventions

There are three arms to this trial. Arm 1: Cognitive Therapy/Memory Reactivation. Arm 2: Cognitive Therapy. Arm 3: Wait-List. Therapy is administered once-daily over 4 days on an individual 30 minute basis. Cognitive Therapy/Memory Reactivation is hospital-based and administered by a psychologist. It includes brief reminding the patient of their traumatic injury, followed by audiorecorded instructions encouraging adaptive appraisals about recovery. The duration of the study for any participant

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

Adults survivors of traumatic injury who are admitted to hospital following injury and report at least moderate distress (as measured on the Acute Stress Disorder Scale)

Exclusion criteria

(a) current substance dependence, (b) inadequate comprehension of English, (c) suicidal intent, (d) psychosis, (e) concurrent psychotropic medication, (f) concurrent psychotherapy, or (g) existence of moderate or severe traumatic brain injury.

Outcome results