None listed
Conditions
Brief summary
This study aims to quantify whether the co-consumption of a high fibre beverage can alter dietary fat absorption of a high fat breakfast meal in ileostomates.
Interventions
The study is a randomised 2x2 factorial design with a high/low fibre beverage consumed with a high (65%)/moderate (40%) fat breakfast test meal. Participants will maintain a typical 'western diet' (total fat providing 30% of daily Energy) for the duration of the intervention. Participants will consume each of the 4 test meals over a two week period to allow for adequate washout period (4 days)between test meals. Dietary compliance will be assessed by dietary records. Ileal efflux is collected a
The study is a randomised 2x2 factorial design with a high/low fibre beverage consumed with a high (65%)/moderate (40%) fat breakfast test meal. Participants will maintain a typical 'western diet' (total fat providing 30% of daily Energy) for the duration of the intervention. Participants will consume each of the 4 test meals over a two week period to allow for adequate washout period (4 days)between test meals. Dietary compliance will be assessed by dietary records. Ileal efflux is collected at regular intervals (2 hours) for the duration of the study to measure fat excretion.
Sponsors
CSIRO Food and Nutrition
Study design
Allocation
Randomised controlled trial
Intervention model
Factorial
Primary purpose
Treatment
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Minimal terminal ileum removed. Willing to comply with diet and alcohol restrictions.
Exclusion criteria
History of drug or alcohol abuse. Participation in any other study within 30 days of commencement of the current study. Any gastrointestinal, renal, hepatic disease or intestinal inflammation. Use of any medication which in the opinion of the investigator could interfere with the study or modify small intestinal function. use of any supplements that contain lipids or dietary fibres which could interfere with the study parameters. Defined or suspected intolerance to the test foods. Person considered unwilling, unlikely or unable to comply with the study protocol and restrictions.
Outcome results
None listed