None listed
Conditions
Brief summary
High dose steroids can raise blood glucose levels. These can cause infections, prolong hospital stay and even rarely result in death. Little is known about the best way to manage patients with ‘steroid diabetes’. We will study various approaches to manage high glucose levels in patients treated with steroids in hospital. We will use minimally invasive continuous glucose monitoring, a contemporary technology, to compare and evaluate in detail two different treatment schedules. One intervention will combine longer acting and mealtime insulin (conventional regimen), and the other will combine liraglutide, a newer non-insulin injection, together with longer acting insulin. The results of this study will provide important objective pilot data on management of patients with ‘steroid diabetes’ in hospital.
Interventions
Basal insulin (0.2 U/kg by subcutaneous injection in the morning) + liraglutide (0.6 mg by subcutaneous injection in the morning) for 72 h
Sponsors
Alfred Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
Glucocorticoid-induced or exacerbated diabetes treated with insulin and/or oral glucose-lowering medication(s) Glucose >= 15 mmol/l
Exclusion criteria
Type 1 diabetes Admission to intensive care Likely to require surgical intervention Likely to be admitted <48 h eGFR <15 ml/min Acute vomiting or history of gastroparesis Known allergy to insulin or GLP-1 agonists Proliferative retinopathy Premenopausal females
Outcome results
None listed