Comparative plasma and cerebrospinal fluid pharmacokinetics of paracetamol following intravenous and oral administration

Plasma and cerebrospinal fluid concentrations of 1 g intravenous paracetamol compared with 1 g and 1.5 g oral paracetamol in adult surgical patients

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12615000322538

Enrollment

Registered

2015-04-09

Start date

2008-02-22

Completion date

2009-03-16

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary purpose of this study was to determine the concentrations of the drug paracetamol in the plasma and cerebrospinal fluid after intravenous and oral administration to adult patients having surgery under spinal anaesthesia.

Interventions

Single bolus dose of 1 g intravenous paracetamol given immediately before induction of spinal anaesthesia

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Investigator)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1. aged 18 years and over 2. presenting for elective surgery under spinal anaesthesia 3. able to communicate in English 4. no contraindication to paracetamol 5. no paracetamol within previous 12 hours

Exclusion criteria

1. aged <18 years 2. not planned for spinal anaesthesia 3. unable to communicate in English 4. contraindication to paracetamol 5. paracetamol within previous 12 hours

Outcome results