None listed
Conditions
Brief summary
It is known that some patients can develop significant reflux following sleeve gastrectomy for morbid obesity, but due to a lack of prospective evaluation the factors underlying the risk for reflux are unknown. In this study, patients before undergoing sleeve gastrectomy will undertake a validated reflux score, have and endoscopy and High Resolution Impedance Manometry and 24 hour Impedance pH testing. 6 months post operatively they will repeat the reflux questionnaire, the manometry and pH testing.
Interventions
To study reflux in patients with morbid obesity prior to and after sleeve gastrectomy. Manometry and oesophageal acid studies are catheter based investigations performed on an outpatient basis without requirement for anaesthesia. Manometry takes 10 minutes to perform, whereas pH (Acid) studies require the subject to have a fine catheter in their oesophagus (placed via the nose) for 24 hours. These studies will be performed pre-operatively and six months following Sleeve Gastrectomy surgery. A sh
To study reflux in patients with morbid obesity prior to and after sleeve gastrectomy. Manometry and oesophageal acid studies are catheter based investigations performed on an outpatient basis without requirement for anaesthesia. Manometry takes 10 minutes to perform, whereas pH (Acid) studies require the subject to have a fine catheter in their oesophagus (placed via the nose) for 24 hours. These studies will be performed pre-operatively and six months following Sleeve Gastrectomy surgery. A short reflux symptom questionnaire will also be filled in.
Sponsors
Dr Michael Talbot
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
morbid obesity consented for sleeve gastrectomy
Exclusion criteria
previous bariatric surgery. contra-indications to sleeve gastrectomy severe pre-op reflux
Outcome results
None listed