None listed
Conditions
Brief summary
Gout, hyperuricemia and hypertension are prevalent in New Zealand. In animal experiments and human studies involving large intakes of free fructose, fructose has been linked to increasing serum uric acid concentrations and elevated blood pressure. More studies are required to test whether uric acid and blood pressure are raised acutely when more realistic fructose intakes contained in real foods are consumed. The objective of this study is to test whether consuming fructose from commonly consumed foods in realistic serving sizes has an affect on acute post-ingestion serum uric acid concentration and blood pressure.
Interventions
This is an acute dietary intervention study in which healthy adults will be randomised to one of four groups. Group 1 - apples; Group 2 - apple juice; Group 3 a commercially available sucrose sweetened beverage (fizzy drink); Group 4 - a fructose drink and a glucose drink. Two serves of food will act as a crossover. For Groups 1 to 3, participants will consume either one serve (one apple; one glass of apple juice; or one can of fizzy drink) or two serves of the respective foods. One serve (one a
This is an acute dietary intervention study in which healthy adults will be randomised to one of four groups. Group 1 - apples; Group 2 - apple juice; Group 3 a commercially available sucrose sweetened beverage (fizzy drink); Group 4 - a fructose drink and a glucose drink. Two serves of food will act as a crossover. For Groups 1 to 3, participants will consume either one serve (one apple; one glass of apple juice; or one can of fizzy drink) or two serves of the respective foods. One serve (one apple, a 250ml glass of juice or a 355ml can of fizzy) are commonly consumed items although a double serve (two apples, two glasses of juice or a 600ml bottle of fizzy) are within the realms of normal consumption for some people. The fructose content of one serve of each of those test foods will be within the range 15-20 g. The order of consumption will be randomised with a two week washout between tests. For Group 4, participants will consume a fructose beverage on one occasion and a glucose beverage on the other, again in randomised order. These are the control foods. The amount of fructose and glucose will be matched to that of the double food serve. At baseline and for one hour after consumption blood samples will be taken for uric acid analysis and blood pressure will be taken at baseline and 70 minutes.
Sponsors
University of Otago
Study design
Allocation
Randomised controlled trial
Intervention model
Other
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
University students
Exclusion criteria
People diagnosed with chronic disease including diabetes mellitus, cardiovascular disease, cancer, and diseases of the digestive system; and women who are pregnant.
Outcome results
None listed