None listed
Conditions
Brief summary
This study is an imaging study which aims to evaluate whether the use of magnetic resonance imaging (MRI) guided audiovisual biofeedback system can improve the precision of lung cancer radiotherapy. Who is it for? You may be eligible to join this study if you are aged 18 years or above and have been diagnosed with stage I-III lung cancer for which you will be treated with radical radiotherapy with or without chemotherapy. Study details All participants will attend 3 additional sessions to standard care. The first session is a breathing training session with audiovisual feedback. This will involve a visual display of a respiratory waveguide. Participants will be asked to regulate their breathing to keep a red ball within the blue wave guide. The aim is for the ball to stay within the line by adjusting breathing by the participant. The second and third sessions participants will undergo MRI scans with and without audiovisual feedback. These MRI sessions will occur pre-radiotherapy treatment and mid-treatment (3 to 6 weeks later). All imaging protocols used are approved clinical procedures. The acquired images will be used to evaluate the reproducibility of respiratory-related tumour motion and whether this leads to improved treatment precision i.e. a reduction in radiotherapy dose delivered to healthy tissues.
Interventions
Lung tumor motion was investigated in lung cancer patients who underwent a breathing training session with AV biofeedback prior to two 3T MRI sessions. The breathing training session was performed to allow patients to become familiar with an AV biofeedback, which utilizes a guiding wave customized for each patient based on a reference breathing pattern. This training session takes approximately 10 minutes. In the first MRI session (pre-treatment) 2D/3D/4D MR images with (1) free breathing (FB) a
Lung tumor motion was investigated in lung cancer patients who underwent a breathing training session with AV biofeedback prior to two 3T MRI sessions. The breathing training session was performed to allow patients to become familiar with an AV biofeedback, which utilizes a guiding wave customized for each patient based on a reference breathing pattern. This training session takes approximately 10 minutes. In the first MRI session (pre-treatment) 2D/3D/4D MR images with (1) free breathing (FB) and (2) AV biofeedback were obtained and the second MRI session was repeated within 3 to 6 weeks (mid-treatment). Each MRI session takes approximately 2 hours to perform. All imaging protocols used are already approved clinical procedures.
Sponsors
University of Sydney
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Stage I-III lung cancer of any histology to be treated with radical radiotherapy with or without chemotherapy Ability to have radiological scans, no contraindications to having an MRI scan Ability to lie flat for about 1 hour 10 minutes
Exclusion criteria
Metastatic disease Pregnant women or those mentally impaired People highly dependent on medical care People unable to undergo MRI exam
Outcome results
None listed