The acute effects of triacylglycerol structure of palmitic acid rich fats on chylomicron composition in lean subjects and those with the Metabolic Syndrome.

In middle aged men with the Metabolic Syndrome, does the ingestion of palmitic acid rich fats, compared with palmitic acid poor fats, acutely affect postprandial chylomicron composition.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12615000147583

Acronym

PALMS: Postprandial effects of Acute Lipid ingestion in the Metabolic Syndrome

Enrollment

Registered

2015-02-17

Start date

2015-02-23

Completion date

2015-10-01

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The ingestion of fat in a meal causes a short term increase in blood lipids (triacylglycerides, or TAG) which contributes to cardiovascular disease (CVD) risk in part through a post-meal inflammatory response. Palm olein (PO), although high in saturated fat, does not cause a heightened TAG or inflammatory response. This is partly due to the chemical positioning of individual fatty acids in the meal fat, which affect the way the fat is broken down in the body. Interesterified palm olein (IPO) is PO where the position has been changed and is used in food manufacturing. Importantly, IPO does not increase post-meal TAG and inflammation as much as PO; however, the TAG and inflammatory effects of eating IPO on individuals at a higher risk of CVD, such as the Metabolic Syndrome (MetS), are still unknown. This study aims to analyse the post-meal TAG and inflammatory responses to PO, IPO, high oleic sunflower oil and lard in healthy middle aged men, and those with MetS. We hypothesise that the post-meal TAG and inflammatory response will be suppressed after IPO ingestion in all subjects, and that subjects with MetS will have a heightened response relative to healthy subjects.

Interventions

Iso-energetic meals, consisting of a muffin and a milkshake, to provide ~ 3.54MJ (846 kcal), 14g protein, 85g carbohydrate and 50g of test fat will be fed on four different occasions separated by at least one week. Intervention test fats: 1. Palm olein (PO) 2. Chemically interesterified palm olein (IPO) 3. Lard (L)

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

Male

Age

45 Years to 60 Years

Healthy volunteers

Inclusion criteria

Group 1: 45-60 years old BMI of 18-25 kg/m2 Healthy (no current or past history of the Metabolic Syndrome as defined by the International Diabetes Federation) Group 2: 45-60 years old BMI greater than 25 kg/m2 Metabolic Syndrome as defined by the International Diabetes Federation: central obesity (waist circumference greater than/equal to 94cm PLUS any two of: * raised TG concentrations (greater than/equal to 1.7 mmol/L or undergoing treatment) * reduced HDL-C (<1.03 mmol/L or undergoing treatment) * raised blood pressure (greater than/equal to 130/85 mmHg or undergoing treatment) * raised fasting plasma glucose (greater than/equal to 5.6 mmol/L or previously diagnoses T2DM)

Exclusion criteria

History of CVD disease/complications (myocardial infarction, angina, stroke) History of cancer Pre-existing diabetes Self reported alcohol intake exceeding a moderate intake (>28 units/week) Abnormal liver function or haematology

Outcome results