None listed
Conditions
Brief summary
The aims of this study are to (1) evaluate the differences in the inflammatory cytokine response to burn injury between women and men (2) determine if obesity/ adiposity contributes to the inflammatory cytokine response to burn injury. We hypothesise that (1) a quantifiable difference in inflammatory cytokines exist between women and men with burn injury, and this correlates with clinical markers of outcome (2) obesity/ adiposity influences the inflammatory cytokine response to burn injury, and this correlates with clinical markers of outcome and survival.
Interventions
The aims of this study are to (1) evaluate the differences in the inflammatory cytokine response to burn injury between women and men (2) determine if obesity/ adiposity contributes to the inflammatory cytokine response to burn injury.
This trial does not involve a true intervention/ exposure.
This trial will recruit women and men with burn injuries involving at least 15% total body surface area.
A 10ml blood sample is obtained during a routine laboratory blood draw at approximately 72 hour
The aims of this study are to (1) evaluate the differences in the inflammatory cytokine response to burn injury between women and men (2) determine if obesity/ adiposity contributes to the inflammatory cytokine response to burn injury. This trial does not involve a true intervention/ exposure. This trial will recruit women and men with burn injuries involving at least 15% total body surface area. A 10ml blood sample is obtained during a routine laboratory blood draw at approximately 72 hours post-injury. The extent of adiposity among male and female burn patients are measured using body mass index (BMI) and percent body fat calculation. The patient’s weight and height are recorded to calculate the BMI (weight/height2). Skin fold caliper measurements are taken at three points (chest, abdomen and thigh in men; triceps, supra-iliac region and thigh in women) to measure subcutaneous fat thickness (Jackson/Pollock 3 Caliper Method) and converted to a body fat percentage using a freely available online calculator http://www.linear-software.com/online.html. Participants are observed from the time of their admission until discharge from hospital.
Sponsors
The Alfred
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* adult patients (at least 18 years of age) * burns greater than or equal to 15% total body surface area (TBSA) * patient admitted to the Victorian Adult Burns Service (The Alfred).
Exclusion criteria
* patients who present (or referred) later than three days after sustaining their injury * patients with multi-trauma injuries (ie neurosurgical, orthopaedic or general surgical injuries)
Outcome results
None listed