None listed
Conditions
Brief summary
The aim of the study is to understand how the body’s metabolism changes in response to mild cold. In general, people with obesity, insulin resistance or diabetes do not increase their metabolic rate as much as those who are insulin sensitive.
Interventions
Each participant will be studied in a purpose built room where the temperature is regulated. The chamber is housed within a large room of the institute. Participants will be studied on three occasions during a total of 4 hours exposure to 20 degrees C or 25 degrees C or 27 degrees C in random order. A minimum of washout of one week will apply between trials.
Participants with known impaired glucose tolerance or Type 2 Diabetes must have been diagnosed for at least 2 years and have their conditi
Each participant will be studied in a purpose built room where the temperature is regulated. The chamber is housed within a large room of the institute. Participants will be studied on three occasions during a total of 4 hours exposure to 20 degrees C or 25 degrees C or 27 degrees C in random order. A minimum of washout of one week will apply between trials. Participants with known impaired glucose tolerance or Type 2 Diabetes must have been diagnosed for at least 2 years and have their condition well controlled. Participants should have residing in Australia for more than 2 years. We will measure metabolic rate, endothelial function, blood pressure, skin temperature, fat and carbohydrate oxidation at rest. Following a fasting blood sample collection after 1.5 hour exposure to selected temperature, participants will ingest a glucose solution (75 g in 300 ml water, OGTT). All measurements will be continued at each half hour after glucose for a further 2 hours. Participants will be required to lie in bed, reading or listening to music in between measurements. A final blood sample for lipids, insulin glucose and liver function tests will be made 2 hours after the glucose drink and conclude the trial.
Sponsors
Mario Soares
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Diagnosis
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Australians of European origin who have resided in Perth for at least 2 years, age range of 20–70 years; overweight or obese (Fat % over 25), weight stable (< +/- 2 kg) in the previous 6 months with no intention for losing weight in the next 6 months; absence of thyroid disease (by history); absence of polycystic ovarian syndrome (by history); non-smokers; non-pregnant, non-lactating; not on hormonal contraception or testosterone replacement therapy or hormonal replacement therapy. Type 2 diabetics on good glucose control as judged by HbA1c <5.4 mmol/L (7%) will be included. Screened participants, will then be provided with the Participant Information sheet.
Exclusion criteria
smokers; pregnant, lactating; on hormonal contraception or testosterone replacement therapy or hormonal replacement therapy, diabetics with poor glucose control, any history of cancer, heart attacks, thyroid conditions
Outcome results
None listed