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Vulnerability to alertness failure in response to sleep deprivation in people with obstructive sleep apnoea

Measurement of vulnerability to alertness failure of people with obstructive sleep apnoea in response to an extended wakefulness challenge

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12615000075583
Acronym
CRC VAFOSA
Enrollment
550
Registered
2015-01-28
Start date
2015-09-15
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The objective of this study is to determine relative vulnerability to alertness failure using a sleep loss (extended wakefulness) challenge in people with obstructive sleep apnoea, and to collect data on related markers of biological function (biomarkers) for comparision. By examining the biomarkers in people who are more vulnerable to alertness failure compared with those who are more resistant, it may be possible to develop new, readily usable measures to predict vulnerability to alertness failure, to allow better tailored care and advice for those individuals.

Interventions

A series of measurements relating to vulnerability to altertness failure will be undertaken at two laboratory visits, one week apart: (1) baseline visit, with measurements undertaken in the evening of the visit, throughout the night and in the morning of the baseline visit (2) an extended wakefulness (sleep loss challenge) visit Details of the extended wakefulness intervention: Each participant's wakefulness will be extended by 3 hours based on their habitual sleep onset time (which will be dete

A series of measurements relating to vulnerability to altertness failure will be undertaken at two laboratory visits, one week apart: (1) baseline visit, with measurements undertaken in the evening of the visit, throughout the night and in the morning of the baseline visit (2) an extended wakefulness (sleep loss challenge) visit Details of the extended wakefulness intervention: Each participant's wakefulness will be extended by 3 hours based on their habitual sleep onset time (which will be determined using actigraphy and sleep diary sent to the participants one week prior to their baseline visit). Measurements will be undertaken in the evening of the visit, throughout the night and in the morning.

Sponsors

Cooperative Research Centre (CRC) for Alertness, Safety and Productivity
Lead SponsorOther Collaborative groups

Study design

Allocation
Non-randomised trial
Primary purpose
Diagnosis

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

(a) Diagnosis of obstructive sleep apnoea (b) Apnoea-hypopnoea index [AHI] greater than or equal to 10 per hour (c) Able to provide informed consent (d) English speaking (to understand instructions for performance tests)

Exclusion criteria

(a) Physician recommended exclusion (b) Unable to or unwilling to consent (c) Central sleep apnoea (central apnoea index > 5/hour) (d) Major co-morbidities (e.g. cardiac or respiratory failure, severe or very severe (GOLD 3/4) chronic obstructive pulmonary disease [COPD], uncontrolled psychiatric illness) (e) No use of continuous positive airways pressure [CPAP] or mandibular advancement splint [MAS] treatment

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026