None listed
Conditions
Brief summary
The objective of this study is to determine relative vulnerability to alertness failure using a sleep loss (extended wakefulness) challenge in people with obstructive sleep apnoea, and to collect data on related markers of biological function (biomarkers) for comparision. By examining the biomarkers in people who are more vulnerable to alertness failure compared with those who are more resistant, it may be possible to develop new, readily usable measures to predict vulnerability to alertness failure, to allow better tailored care and advice for those individuals.
Interventions
A series of measurements relating to vulnerability to altertness failure will be undertaken at two laboratory visits, one week apart: (1) baseline visit, with measurements undertaken in the evening of the visit, throughout the night and in the morning of the baseline visit (2) an extended wakefulness (sleep loss challenge) visit Details of the extended wakefulness intervention: Each participant's wakefulness will be extended by 3 hours based on their habitual sleep onset time (which will be determined using actigraphy and sleep diary sent to the participants one week prior to their baseline visit). Measurements will be undertaken in the evening of the visit, throughout the night and in the morning.
Sponsors
Study design
Eligibility
Inclusion criteria
(a) Diagnosis of obstructive sleep apnoea (b) Apnoea-hypopnoea index [AHI] greater than or equal to 10 per hour (c) Able to provide informed consent (d) English speaking (to understand instructions for performance tests)
Exclusion criteria
(a) Physician recommended exclusion (b) Unable to or unwilling to consent (c) Central sleep apnoea (central apnoea index > 5/hour) (d) Major co-morbidities (e.g. cardiac or respiratory failure, severe or very severe (GOLD 3/4) chronic obstructive pulmonary disease [COPD], uncontrolled psychiatric illness) (e) No use of continuous positive airways pressure [CPAP] or mandibular advancement splint [MAS] treatment