The effect of flavonoids from cherries on memory and cognition in older adults with mild to moderate dementia

Assessment of change in cognitive function in people with mild to moderate dementia after daily consumption of flavonoid-rich cherry juice or low-flavonoid apple juice over 12 weeks.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614001298606

Enrollment

Registered

2014-12-11

Start date

2011-09-23

Completion date

2013-01-21

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to assess whether further cognitive decline can be delayed or prevented in people with mild to moderate dementia through the consumption of flavonoids in cherry juice over 12 weeks. Secondary outcomes included anti-inflammatory effects, changes in functional and physical ability and depressive symptomatology.

Interventions

Over 12 weeks participants receive 200ml/day of orally administered cherry juice containing 186mg/L anthocyanins (ORAC 59 TE/g). The sweet, 100% Bing cherry juice is produced using a novel method that aims to retain the phenolic bioactives, developed by a research company (Agritechnology) based in Orange, NSW, Australia. Adherence to the intervention was assessed using a self reported diary check box and monitoring of returned juice bottles.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Caregiver)

Eligibility

Sex/Gender

All

Age

70 Years to No maximum

Healthy volunteers

Inclusion criteria

>70years MMSE score 10 - 24

Exclusion criteria

MMSE > 24 Confounding health conditions such as dysphasia.

Outcome results