None listed
Conditions
Brief summary
Severe sepsis is one of the leading causes of acute kidney injury (AKI). Of patients with sepsis in the ICU, 31–61% have AKI. Both the incidence of severe sepsis and AKI are increasing. Patients with septic AKI have worse outcome than septic patients without AKI in terms of longer ICU and hospital stays and higher mortality. Because the current RIFLE classification does not integrate biomarkers for early diagnosis, severity staging and predicting prognosis of AKI, the present study will be conducted to determine the association between some biomarkers in predicting the progression or recovery of septic AKI.
Interventions
Urine samples will be collected from existing foley cathethers and blood samples collected from arterial catheters from enrolled patients who are recognized as having sepsis with acute renal injury, from admission and every other day for up to 10 days or until these patients are discharged to ward from ICU or deceased.
Sponsors
Dr. Hsin-I Tsai
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
>18 years old without known previous renal diseases admitted to our surgical ICU in the absence of any one of the exclusion criteria
Exclusion criteria
1. Urinary tract infection on admission 2. Chronic kidney disease (glomerular filtration rate <60ml/min/1.73m2) for more than 3 months) 3. Patients requiring routine dialysis program 4. Renal transplantation 5. Inflammatory bowel disease
Outcome results
None listed