Intravenous low dose Ketamine injection versus Dexmedetomidine infusion for prevention of intraoperative shivering during spinal anesthesia

Sixty patients of both sexes between 20 to 50 years old undergoing elective lower abdominal surgery and elective orthopedic lower limb surgery under spinal anesthesia receiving low dose ketamine injection versus dexmedetomidine infusion to control post-spinal shivering in a clinical trial study with dexmedetomidine advantage.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614001246673

Enrollment

Registered

2014-11-27

Start date

2013-01-15

Completion date

2013-12-20

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Shivering is considered one of the most common adverse effects occurring during spinal anesthesia. Besides causing patient discomfort, shivering also interferes with patient monitoring and increases tissue oxygen demand. The present study was conducted to compare the effectiveness of iv low dose Ketamine (0.25mg/kg) and dexmedetomidine iv infusion in prevention of shivering during spinal anesthesia. Dexmedetomidine infusion exerts a beneficial dual effect as an anti-shivering and sedating agent during spinal anesthesia without any major adverse reactions. Therefore, we concluded that dexmedetomidine infusion is a good choice and better than low dose ketamine during spinal anesthesia when shivering is considered a problem.

Interventions

Patients included in group D received Dexmedetomidine infusion (loading dose of 1mcg/kg over 10 minutes followed by a maintenance dose of 0.4mcg/kg/h) started immediately after giving spinal anesthesia for elective lower abdominal surgeries and elective lower limb orthopedic surgeries to control post-spinal anesthesia shivering and maintained until completion of surgery.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Healthy volunteers

Inclusion criteria

Patients undergoing elective lower abdominal surgery and elective orthopedic lower limb surgery were included in the study. Patients selected were American Society of Anesthesiologists (ASA) I and II physical status.

Exclusion criteria

Patients with thyroid disease, Parkinson's disease, dysautonomia, Raynaud's syndrome, cardiopulmonary disease, a history of allergy to the agents to be used, a need for blood transfusion during surgery, an initial core temperature > 37.5 degree C or < 36.5 degree C, a known history of alcohol use, use of sedative-hypnotic agents, use of vasodilators, or having contraindications to spinal anesthesia were excluded from the study.

Outcome results