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Does the bubble­-positive expiratory pressure (PEP) device improve secretion clearance compared to the active cycle of breathing technique (ACBT) or no intervention (control) in people with non­-cystic fibrosis bronchiectasis?

Does the bubble­-positive expiratory pressure (PEP) device improve secretion clearance compared to the active cycle of breathing technique (ACBT) or no intervention (control) in people with non­-cystic fibrosis bronchiectasis?

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12614001233617
Enrollment
35
Registered
2014-11-25
Start date
2015-04-09
Completion date
2016-12-09
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The primary aim of this study is to determine the effectiveness of bubble­-PEP device compared to the active cycle of breathing technique (ACBT) or no intervention in clearing secretions in people with non­-CF bronchiectasis. The hypothesis is that the bubble­PEP is not inferior to the ACBT and is superior to no intervention in clearing secretions. Secondary aims will be to evaluate the acceptability and perceived benefits of the bubble­PEP device by participants.

Interventions

Bubble-positive expiratory pressure (PEP) device: Administered: Mouth-piece PEP device. Pressure of 10-20cm H2O. 1 cycle = 3-4 deep breaths followed by 10 repetitions of blowing into the Bubble-PEP device and then 2 huffs and coughs. Repetitive cycles for a total intervention time of 30 minutes (with rest periods as needed). Adherence will be monitored by the physiotherapist delivering the intervention.

Sponsors

Prince of Wales Hospital
Lead SponsorHospital

Study design

Allocation
Randomised controlled trial
Primary purpose
Treatment

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

- Confirmed diagnosis of bronchiectasis on CT ­- Reported daily sputum production ­- Ability to perform airway clearance techniques

Exclusion criteria

- Primary diagnosis of CF, asthma, COPD - Any contraindications to use of PEP e.g. severe haemoptysis, pneumothorax, recent AMI, exacerbation in the previous 4 weeks - Inability to consent or understand English - Cognitive impairment (MMSE<24)

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026