None listed
Conditions
Brief summary
The aim of this study is to investigate brain structure, cerebral blood perfusion, cognition, and microsleep propensity at baseline and following 6 months of CPAP treatment in people with moderate obstructive sleep apnoea (OSA) compared to (1) people without OSA and (2) people with untreated moderate OSA. We hypothesize that: (1) CPAP treatment will improve cerebral perfusion while awake at the 6-month follow-up. (2) There is a relationship between OSA-related decreased cerebral perfusion and cognitive impairment. (3) CPAP treatment will reduce microsleep propensity.
Interventions
Six months of continuous positive airway pressure (CPAP) for at least 4 hours per night. CPAP works by blowing air into the pharynx during sleep thereby raising the air pressure sufficiently to hold the airway open.
This treatment will be administered via a mask around the mouth and nose. The dose setting for each patient is set by the CPAP device that uses an algorithm to set the optimal dose. This dosage will be monitored by the Sleep Unit.
Compliance will be monitored remotely by downloadi
Six months of continuous positive airway pressure (CPAP) for at least 4 hours per night. CPAP works by blowing air into the pharynx during sleep thereby raising the air pressure sufficiently to hold the airway open. This treatment will be administered via a mask around the mouth and nose. The dose setting for each patient is set by the CPAP device that uses an algorithm to set the optimal dose. This dosage will be monitored by the Sleep Unit. Compliance will be monitored remotely by downloading the data cards used in the CPAP device.
Sponsors
Dr. Carrie Innes
Study design
Allocation
Non-randomised trial
Intervention model
Other
Primary purpose
Prevention
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
All participants: Be at least 18 yrs but no older than 80 yrs. Normal time to bed between the hours of 0900 pm and 1200 am. Normal time in bed of 7 to 9 hours. Have a basic ability in English (verbal and written). Participants with moderate OSA: Be diagnosed with moderate OSA (15 - 29 OSA-related events per hour during Level 2 Sleep Study. Participants without OSA: Have <10 OSA-related events per hour during Level 2 Sleep Study.
Exclusion criteria
Currently receiving or previously received OSA treatment. A history of physiological, psychiatric, or neurological disorders that could affect or is affecting sleep behaviour, fatigue, cerebral perfusion or brain structure (e.g. chronic obstructive pulmonary disease, congestive heart disease, diabetes, heart failure, hypertension > 150/90, migraine, myocardial infarction, stroke, previous brain surgery, stroke, traumatic brain injury, etc., but not mild depression). Currently taking any medication that could impact on cerebral perfusion (e.g., ACE inhibitors, nitrates …). Not willing or unable to give consent. Not willing or unable to remove metal that could either be harmful to the participant during a MRI or could likely create MRI artefacts that negatively affect the quality of the scan. Based on current Sleep Unit criteria, not have any reason for urgent treatment.
Outcome results
None listed