None listed
Conditions
Brief summary
Liver biopsy is an important procedure for the diagnosis and evaluation of liver disease and it can be associated with pain. For years this procedure was performed in Dunedin hospital without Pethidine give prior to the investigation. Two years ago we started giving pethidine immediately before a liver biopsy was performed. This was done to potentially decrease the amount of pain-relief required following the procedure. A recent analysis of our data indicated that this was indeed the case however, an unknown number of patients might have been given Pethidine unnecessarily because they never experienced any pain after the procedure. With this study we would like to assess how effective pre-procedural Pethidine is in controlling pain and anxiety during and after the procedure.
Interventions
Patients undergoing percutaneous liver biopsy receive 50mg of intravenous pethidine and 10mg of intravenous metoclopramide as premedication.
Sponsors
Gastroenterology unit, Dunedin Hospital
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Prevention
Masking
Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
All
Age
16 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
All patients undergo percutaneous liver biopsy at Dunedin hospital
Exclusion criteria
1) Patients with previous allergic reaction to pethidine or metoclopramide; 2) Patients with clotting disorders and abnormal prothrombin time with international normalized ratio (INR) of greater than 1.5 or thrombocytopenia with platelet less than 50 x 109 per litre; 3) abdominal ultrasound revealed a contraindication to PLB such as massive ascites, intrahepatic duct dilatation, or focal lesion; 4) patients without a telephone for study follow up; and 5) patients with a solitary lesion that required target biopsy under ultrasound guidance
Outcome results
None listed