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Routine Use Of 0.9% Saline Vs. Routine Use Of Plasma-Lyte 148 (Registered Trademark) For Intravenous Fluid Therapy In Emergency Department Patients

Routine Use Of 0.9% Saline Vs. Routine Use Of Plasma-Lyte 148 'Registered Trademark' For Intravenous Fluid Therapy In Emergency Department Patients: a comparison of kidney function, hospital length of stay, intensive care admission and mortality.

Status
Withdrawn
Phases
Phase 4
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12614001178639
Acronym
SPLITED
Enrollment
3000
Registered
2014-11-10
Start date
2015-01-01
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This will be an audit to provide preliminary data to address whether the use of Plasma-Lyte148 'Registered Trademark' as default intravenous fluid results in better clinical outcomes compared to current standard practice. The audit will be conducted with two 12 week periods. During the control period patients admitted to Wellington Regional Hospital from ED would have received intravenous fluid at the discretion of the treating doctors, in which 0.9% saline would have been the preferred intravenous fluid. This will be compared a 12 weeks where the preferred fluid will be Plasma-Lyte148 'Registered Trademark'. The outcomes that will be recorded will be kidney function, hospital length of stay, intensive care admission and mortality.

Interventions

Single centre, open label, before and after audit. One month prior to the intervention period there will be Emergency Department (ED) staff education and logistic arrangements for changing to Plasma-Lyte 148 'Registered Trademark' as the default IV fluid. During the 12 week intervention period Plasma-Lyte 148 'Registered Trademark' will be used as the default primary crystalloid fluid. The dosing regimen is at the discretion of the treating clinician. A random sample of 100 patients that rece

Single centre, open label, before and after audit. One month prior to the intervention period there will be Emergency Department (ED) staff education and logistic arrangements for changing to Plasma-Lyte 148 'Registered Trademark' as the default IV fluid. During the 12 week intervention period Plasma-Lyte 148 'Registered Trademark' will be used as the default primary crystalloid fluid. The dosing regimen is at the discretion of the treating clinician. A random sample of 100 patients that received fluid in emeregency department will be assessed to see extact type and amount of given.

Sponsors

Medical Research Institute of New Zealand
Lead SponsorCharities/Societies/Foundations

Study design

Allocation
Non-randomised trial
Intervention model
Other
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Patients >18 year presenting to ED and subsequently admitted to hospital who have a serum creatinine measured in the ED

Exclusion criteria

Patients on renal replacement therapy for end stage renal failure.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026