The role of Intraperitoneal Ropivacaine in Laparoscopic Appendicectomy: A prospective, double blinded randomised control study

The effect of intraperitoneal Ropivacaine on post-laparoscopic pain in appendicectomy patients compared with the effect of intraperitoneal normal saline.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614001161617

Enrollment

Registered

2014-11-04

Start date

2015-04-06

Completion date

2017-08-04

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study investigates the analgesic effect of intraperitoneal injection of a long acting local anaesthetic agent (Ropivacaine) during laparoscopic (keyhole) appendicectomy. Trial participants will be randomly divided into two groups. One group will receive intraperitoneal Ropivacaine during laparoscopic appendicectomy while the other will receive normal saline. The consumption quantity of total Fentanyl analgesia, the presence of shoulder tip pain and post surgery nausea or vomiting will be recorded up to 16 hours post surgery. The study aims to determine whether the use of Ropivacaine during laparoscopic appendectomy is an useful analgesic adjunct. The primary aim of this study will be to determine whether using Ropivacaine will reduce total amount of analgesia used, hence reducing post-operative pain, and its effect on the incidence of post laparoscopic appendicectomy shoulder tip pain and nausea or vomiting.

Interventions

Intraperitoneal injection of 0.5ml per kilogram of 0.2% Ropivacaine after the insertion of suprapubic port and another 0.5ml per kilogram of the same solution at the end of laparoscopic appendicectomy.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

All patients undergoing laparoscopic appendicectomy at Armadale Hospital

Exclusion criteria

1. Medical or psychiatric conditions that compromise patient’s ability to give informed consent 2. Pregnant or breast feeding 3. Allergies to paracetamol, fentanyl or ropivacaine. 4. Liver failure 5. Conversion from laparoscopic surgery to open surgery 6. Presence of faecal peritonitis 7. ASA III 8. Iatrogenic perforation 9. Chronic pain syndrome 10. Operative time more than 2 hours. 11. Drain insertion 12. Weight >100kg

Outcome results