A study for comparison of onset and duration of block in 3 groups of participants following ultrasound guided supraclavicular brachial plexus block using 0.5% Ropivacaine or 0.5% Ropivacaine with dexmedetomidine or 0.5% Ropivacaine with midazolam.

Comparative study of additive to ropivacaine to assess the block characteristics following brachial plexus block for patients undergoing elective upper limb orthopaedic surgery.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614001151628

Enrollment

Registered

2014-10-31

Start date

2014-08-01

Completion date

2014-12-05

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Study is aimed at comparing the block characteristics of ultrasound guided supraclavicular brachial plexus block in 3 groups of patients. One group receiving plain ropivacaine (a local anaesthetic) without any additive, second group receiving ropivacaine with dexmedetomidine as additive and third group receiving ropivacaine with midazolam as additive. Previous studies suggest that additives prolong the duration of blockade. Our study is comparing two different additives.

Interventions

3 Groups of patients based on the study medication used. Group R: Injection 30 ml 0.5% Ropivacaine + 1 ml 0.9% Saline Group D: Injection 30 ml 0.5% Ropivacaine + 1mcg/kg of Dexmedetomidine in 1ml 0.9% saline Group M: Injection 30 ml 0.5% Ropivacaine + 0.05mg/kg of Midazolam in 1ml 0.9% saline All medications administered in periplexus region around brachial plexus under ultrasound guidance.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

Patients aged between 18 to 60 years, weighing >50 kilograms, belonging to American Society of Anaesthesiologists physical status 1 or 2, posted for elective upper limb (elbow or forearm) orthopaedic surgery under supraclavicular brachial plexus block.

Exclusion criteria

Patients refusing nerve block, having brachial plexus deficits, on anticoagulants or having bleeding disorders, with history of seizures or local anaesthetic allergy and belonging to American Society of Anaesthesiologists physical status 3 or 4.

Outcome results