Probiotic microflora in the gut following ingestion of fermented milk.

Recovery of faecal Lactobacillus casei strain Shirota (LcS) from the Intestine of Healthy Adults after Intake of Fermented Milk.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614001136695

Enrollment

Registered

2014-10-27

Start date

2014-10-24

Completion date

2014-10-24

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study aims to investigate the efficacy of daily supplementation of a commercially available fermented milk product (Yakult) to increase gut microbial content. Specifically, it is hypothesized that ingestion of Yakult for 14 days will increase the concentration of intestinal Lactobacillus casei strain Shirota (LcS) in 25 young healthy adults (18 - 35 yr).

Interventions

Daily ingestion of a single dose (1 bottle, 65mL) of a commercially available fermented milk product (Yakult), containing 6.5 billion Lactobacillus casei Shirota strain (probiotic) per bottle, for 14 days. Participants will be asked to complete a daily questionnaire to provide details on adherence.

Study design

Allocation

Non-randomised trial

Intervention model

Single group

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

Community dwelling adults

Exclusion criteria

Body mass index less than 18.5 or above 25 kg/m2. History of gastrointestinal disorders (constipation, diarrhea, abdominal pain, irritable bowel syndrome). Disorders requiring a special diet. Respiratory or gastrointestinal illness in the 30 days prior to the study. Use of systemic antibiotics or antimycotics medication in the 30 days prior to the study. Use of antidiarrheal or laxative medications in the 30 days prior to the study. History of asthma or allergies. Use of immunomodulating medications and participation in any other studies within 2 months prior to entry into the study.

Outcome results