A double-blinded, randomised control trial to compare intraoperative morphine and methadone on the post-operative pain scores and analgesic requirements after shoulder arthroscopic surgery

In patients undergoing elective arthroscopic shoulder surgery, is a single intraoperative dose of intravenous morphine more effective than a single intraoperative dose of intravenous methadone in reducing post-operative analgesic patient-controlled-analgesia (PCA) requirements and visual analogue pain score (VAS)? A double-blinded, randomised control trial.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12614001115628

Enrollment

Registered

2014-10-22

Start date

2014-12-29

Completion date

2015-07-31

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

To assess the perioperative analgesic requirements of single dose intraoperative, intravenous methadone versus single dose, intraoperative, intravenous morphine during shoulder arthroscopy.

Interventions

Intravenous methadone will be injected at dose of 0.15mg/kg (0.1mg/kg if age >70) after induction and before initial incision

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used) (Subject, Caregiver)

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

Consecutive patients admitted to Nepean Private Hospital during the study period who are undergoing shoulder arthroscopy Able to give consent for procedure ASA I-III

Exclusion criteria

Chronic opiate use (taken opiates regularly in the month before procedure) Opiate use in previous 48 hours History of drug abuse Psychiatric history Age under 18 and over 85 Chronic renal failure (eGFR < 30mL/min/1.73m^2) Chronic liver failure (cirrhosis/fulminant liver failure) Weight >120kg Allergies to study drugs (morphine/methadone) Known contraindications to methadone (hypothyroidism, Addison’s disease, prostatic hypertrophy, urethral stricture) Taking medications known to induce or inhibit cytochrome p450 (antifungals, macrolide antibiotics, SSRIs, antivirals) Individuals known to be pregnant Those who are not suitable for PCA

Outcome results